中国南方东部地区乳腺癌患者脂肪组织中的多溴联苯醚水平与预后生物标志物及无进展生存期的关系：一项基于医院的研究。
Adipose tissue levels of polybrominated diphenyl ethers in relation to prognostic biomarkers and progression-free survival time of breast cancer patients in eastern area of southern China: A hospital-based study.
机构信息
Central Laboratory, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou, Guangdong, 515041, China; School of Public Health, Shantou University, Shantou, 515041, China.
Department of Laboratory Medicine, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, 515041, Shantou, Guangdong, China.
出版信息
Environ Res. 2023 Jan 1;216(Pt 4):114779. doi: 10.1016/j.envres.2022.114779. Epub 2022 Nov 9.
Evidence indicates that individual or groups of polybrominated diphenyl ethers (PBDEs) are associated with risk of breast cancer (BC). Epidemiological studies of PBDEs and BC progression are scarce. This study aimed to investigate the relationships between PBDE burdens in adipose tissues and prognostic biomarkers of BC as well as progression-free survival (PFS) of patients for the first time. The concentrations of 14 PBDE congeners in breast adipose tissues of 183 cases from the eastern area of southern China were analyzed by gas chromatography-mass spectrometry (GC-MS). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression models for the associations between PBDE levels and prognostic biomarkers. Kaplan-Meier and Cox regression analyses were conducted to identify the correlations between PBDEs and PFS. The results showed that BDE-99 and 190 levels were positively associated with clinical stage and N stage respectively (OR = 2.61 [1.26-5.40], OR = 2.78 [1.04-7.46]). Concentrations of BDE-28 and BDE-183 were negatively associated with the expression of estrogen receptor (ER) (OR = 0.30 [0.11-0.81]; 0.39 [0.15-0.99]) and progesterone receptor (PR) (OR = 0.36 [0.14-0.92]; 0.37 [0.15-0.91]), and increased BDE-47 was associated with lower human epidermal growth factor receptor 2 (HER2) expression (OR = 0.44 [0.23-0.86]). Adipose levels of BDE-71, 99, 138, 153, 154 and total PBDEs were positively associated with p53 expression (all P < 0.05). Finally, BDE-47, 99 and 183 were considered as independent prognostic factors for shorter PFS in the Cox models (adjusted hazard ratios = 3.14 [1.26-7.82]; 2.25 [1.03-4.94]; 2.60 [1.08-6.25], respectively). The recurrence risk and prognosis of BC may be closely bound to the body burdens of certain PBDE congeners. Further epidemiological and experimental studies are needed for confirmation.
有证据表明，个体或多溴二苯醚（PBDEs）群体与乳腺癌（BC）的风险相关。关于 PBDEs 和 BC 进展的流行病学研究很少。本研究首次旨在调查脂肪组织中 PBDE 含量与 BC 预后生物标志物以及患者无进展生存期（PFS）之间的关系。通过气相色谱-质谱（GC-MS）分析了来自中国东南部东部地区的 183 例病例的乳房脂肪组织中 14 种 PBDE 同系物的浓度。使用逻辑回归模型估计 PBDE 水平与预后生物标志物之间的关联的优势比（OR）和 95％置信区间（CI）。进行 Kaplan-Meier 和 Cox 回归分析以确定 PBDEs 与 PFS 之间的相关性。结果表明，BDE-99 和 190 水平分别与临床分期和 N 分期呈正相关（OR=2.61[1.26-5.40]，OR=2.78[1.04-7.46]）。BDE-28 和 BDE-183 的浓度与雌激素受体（ER）（OR=0.30[0.11-0.81]；0.39[0.15-0.99]）和孕激素受体（PR）（OR=0.36[0.14-0.92]；0.37[0.15-0.91]）的表达呈负相关，并且 BDE-47 的增加与较低的人表皮生长因子受体 2（HER2）表达相关（OR=0.44[0.23-0.86]）。脂肪中的 BDE-71、99、138、153、154 和总 PBDEs 与 p53 表达呈正相关（均 P<0.05）。最后，在 Cox 模型中，BDE-47、99 和 183 被认为是较短 PFS 的独立预后因素（调整后的危险比=3.14[1.26-7.82]；2.25[1.03-4.94]；2.60[1.08-6.25]）。BC 的复发风险和预后可能与某些 PBDE 同系物的体内负担密切相关。需要进一步的流行病学和实验研究来证实。
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