Department of Preventive Medicine, Shantou University Medical College, Shantou, 515041, Guangdong, China.
Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
Environ Res. 2022 Nov;214(Pt 3):114096. doi: 10.1016/j.envres.2022.114096. Epub 2022 Aug 13.
Animal studies have indicated that exposure to polybrominated diphenyl ethers (PBDEs) during development can permanently affect blood/liver lipid balance. However, no epidemiological study has assessed the relationship between PBDEs in adipose tissues and blood lipid metabolism. In this study, we explored the associations between PBDEs levels in female adipose tissues and lipid profiles. We recruited 150 female patients undergoing plastic surgery from hospital in Shantou, China, collected their characteristics, clinical information, and adipose tissue samples. Fourteen PBDE congeners in adipose tissues were analyzed by gas chromatography-mass spectrometry (GC-MS). Multiple linear and logistic regression models were used to explore the relationships between PBDEs and lipid profiles, while restricted cubic spline (RCS) regression and Bayesian kernel machine regression (BKMR) models were used to evaluate the nonlinearity of mixtures. Median levels of ΣPBDEs and dominant congeners BDE-153, -209, and -183 in adipose tissues were 73.91, 26.12, 14.10 and 9.01 ng/g lipid, respectively. In the multiple linear model, BDE-153 and BDE-209 were negatively associated with triglycerides (TG), similarly for BDE-190 and total cholesterol (TC). While in the adjusted logistic models, BDE-138 was negatively associated with TC (OR = 0.76, 95%CI: 0.58, 0.99) and total lipids (TL) (OR = 0.76, 95%CI: 0.58, 0.99). Diastolic blood pressure was positively correlated with BDE-28 and BDE-71 (P < 0.05). Furthermore, a non-linear relationship was observed in BDE-138 and blood lipid levels using a RCS model (P<0.05). BKMR analysis indicated that with the cumulative levels across PBDEs increased, the health risks of hypertriglyceridemia gradually rebounded, and the health risks of hypercholesterolemia and high total lipid gradually rebounded and then declined, but without statistical significance. PBDEs pollution was still prevalent in Shantou city, and several PBDE congeners were significant risk factors for dyslipidemia and blood pressure alteration. There exist deleterious effects of PBDEs and blood lipids.
动物研究表明，发育过程中接触多溴二苯醚 (PBDEs) 会永久性地影响血液/肝脏脂质平衡。然而，目前还没有流行病学研究评估脂肪组织中 PBDEs 与血脂代谢之间的关系。在这项研究中，我们探讨了女性脂肪组织中 PBDEs 水平与血脂谱之间的关系。我们招募了 150 名在中国汕头医院接受整形手术的女性患者，收集了她们的特征、临床信息和脂肪组织样本。采用气相色谱-质谱联用仪（GC-MS）分析了 14 种 PBDE 同系物。多线性和逻辑回归模型用于探索 PBDEs 与血脂谱之间的关系，而受限立方样条（RCS）回归和贝叶斯核机器回归（BKMR）模型用于评估混合物的非线性关系。脂肪组织中 ΣPBDEs 及主要同系物 BDE-153、-209 和 -183 的中位数水平分别为 73.91、26.12、14.10 和 9.01 ng/g 脂质。在多线性模型中，BDE-153 和 BDE-209 与甘油三酯（TG）呈负相关，BDE-190 和总胆固醇（TC）也呈负相关。而在调整后的逻辑模型中，BDE-138 与 TC（OR=0.76，95%CI：0.58，0.99）和总脂质（TL）（OR=0.76，95%CI：0.58，0.99）呈负相关。舒张压与 BDE-28 和 BDE-71 呈正相关（P<0.05）。此外，使用 RCS 模型观察到 BDE-138 与血脂水平之间存在非线性关系（P<0.05）。BKMR 分析表明，随着 PBDEs 累积水平的增加，高甘油三酯血症的健康风险逐渐回升，高胆固醇血症和高总脂质血症的健康风险逐渐回升后下降，但无统计学意义。汕头市的 PBDEs 污染仍然很普遍，有几个 PBDE 同系物是血脂异常和血压改变的显著危险因素。PBDEs 对血液有不良影响。
