患有类切-东综合征的小鼠的成纤维细胞和巨噬细胞含有微管和肌动蛋白束。
Fibroblasts and macrophages of mice with the Chediak-Higashi-like syndrome have microtubules and actin cables.
作者信息
Frankel F R, Tucker R W, Bruce J, Stenberg R
出版信息
J Cell Biol. 1978 Nov;79(2 Pt 1):401-8. doi: 10.1083/jcb.79.2.401.
Abstract
Cells of the beige mouse contain abnormally large lysosomes and show enhanced capping of concanavalin A. It has been suggested that these phenomena may be secondary to a defect in microtubule polymerization. We have examined the cytoskeleton of beige mouse cells by indirect immunofluorescence and find the number and distribution of microtubules and actin cables to be indistinguishable from those of normal control cells.
摘要
米色小鼠的细胞含有异常大的溶酶体，并且伴刀豆球蛋白A的帽化增强。有人提出，这些现象可能继发于微管聚合缺陷。我们通过间接免疫荧光检查了米色小鼠细胞的细胞骨架，发现微管和肌动蛋白索的数量和分布与正常对照细胞没有区别。
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Fibroblasts and macrophages of mice with the Chediak-Higashi-like syndrome have microtubules and actin cables.患有类切-东综合征的小鼠的成纤维细胞和巨噬细胞含有微管和肌动蛋白束。
J Cell Biol. 1978 Nov;79(2 Pt 1):401-8. doi: 10.1083/jcb.79.2.401.
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本文引用的文献
1
Muscle-like contractile proteins and tubulin in synaptosomes.突触小体中的肌肉样收缩蛋白和微管蛋白。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4472-6. doi: 10.1073/pnas.71.11.4472.
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Correction of characteristic abnormalities of microtubule function and granule morphology in Chediak-Higashi syndrome with cholinergic agonists.用胆碱能激动剂纠正切-东综合征中微管功能和颗粒形态的特征性异常。
J Clin Invest. 1976 May;57(5):1239-47. doi: 10.1172/JCI108392.
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