钛/钪放射性核素发生器系统及分离化学的现状。
Current State of Ti/Sc Radionuclide Generator Systems and Separation Chemistry.
机构信息
Department of Chemistry, Graduate Center of the City University of New York, New York, NY 10016, USA.
Department of Chemistry, Lehman College of the City University of New York, New York 10468, USA.
出版信息
Curr Radiopharm. 2023;16(2):95-106. doi: 10.2174/1874471016666221111154424.
Abstract
In recent years, there has been an increased interest in Ti/Sc generators as an onsite source of Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current Ti/Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the Sc for potential PET radiopharmaceuticals.
摘要
近年来，人们对 Ti/Sc 发生器越来越感兴趣，因为它可以作为一种现场来源，为医疗应用提供 Sc，而无需使用近旁回旋加速器。Sc 的半衰期（3.97 小时）相对较短，正电子分支比（94.3%）较高，使其成为正电子发射断层扫描（PET）成像的可行候选物。本综述讨论了当前的 Ti/Sc 发生器设计，重点介绍了它们的化学性质、缺点、洗脱后处理以及 Sc 作为潜在的 PET 放射性药物的相关临床前研究。
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