PhD Program in Chemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Chemistry, Lehman College, CUNY, Bronx, NY 10468, USA.
Department of Chemistry and Environmental Science, Medgar Evers College, CUNY, Brooklyn, NY 11225, USA.
J Chromatogr A. 2024 Sep 13;1732:465245. doi: 10.1016/j.chroma.2024.465245. Epub 2024 Aug 8.
Towards application of Sc for diagnostic nuclear medicine, a Ti/Sc generator based on an inorganic resin has been evaluated. Unlike other radionuclide generators used for medical applications, the long-term retention of the parent Ti is vital due to its long half life. Herein, tin dioxide (SnO), a robust inorganic-based resin, has been synthesized and used as the stationary phase for a Ti/Sc generator. The sorption behavior of Ti/Sc was tested on SnO with varying acids, concentrations, and times. Preliminary batch study results showed >88 % Ti retention to the resin at lower acid concentrations (0.05 M HNO and 0.05 M HCl). A pilot generator was evaluated for a year, demonstrating 85.3 ± 2.8 % Sc elution yields and 0.71 ± 0.14 % Ti breakthrough in 5 M HNO. Based on capacity studies, a 7.4 MBq (200 µCi) upscaled generator system was constructed for further evaluation of the SnO resin stability and the efficacy of the eluted Sc for radiolabeling. Sc could be regularly eluted from this generator in 5 M HNO with an overall average radiochemical yield 84.7 ± 9.5 %. Post-elution processing of the Sc with DGA-normal resin removed all Ti present and allowed for high Sc-DOTA labeling yields of 94.2 ± 0.5 %. Overall, SnO has been shown to be a viable material for a Ti/Sc generator.
为了将 Sc 应用于诊断核医学，我们评估了一种基于无机树脂的 Ti/Sc 发生器。与其他用于医疗应用的放射性核素发生器不同，由于其半衰期长，母体 Ti 的长期保留至关重要。在此，我们合成了二氧化锡（SnO）这种坚固的无机树脂，并将其用作 Ti/Sc 发生器的固定相。我们测试了 Ti/Sc 在不同酸、浓度和时间条件下在 SnO 上的吸附行为。初步批处理研究结果表明，在较低的酸浓度（0.05 M HNO 和 0.05 M HCl）下，超过 88%的 Ti 保留在树脂上。我们评估了一个为期一年的试点发生器，结果表明，在 5 M HNO 中，洗脱产率为 85.3±2.8%，Ti 突破率为 0.71±0.14%。基于容量研究，构建了一个 7.4 MBq（200 µCi）的升级发生器系统，以进一步评估 SnO 树脂的稳定性和洗脱的 Sc 用于放射性标记的效果。可以在 5 M HNO 中定期从该发生器中洗脱 Sc，总平均放射化学产率为 84.7±9.5%。用 DGA-正常树脂对洗脱后的 Sc 进行后处理可以去除所有存在的 Ti，并实现 94.2±0.5%的高 Sc-DOTA 标记产率。总的来说，SnO 已被证明是一种可行的 Ti/Sc 发生器材料。
