Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
Transl Vis Sci Technol. 2022 Nov 1;11(11):9. doi: 10.1167/tvst.11.11.9.
The purpose of this study was to develop and test a programmable closed-loop system for tracking, modulating, and assessing dynamic iris behavior, including in the mid-dilated position.
A programmable closed-loop iris control system was developed by customizing an ANTERION OCT device (Heidelberg Engineering, Heidelberg, Germany). Custom software was developed to store camera and optical coherence tomography (OCT) images, track pupillary diameter (PD), control a light-emitting diode (LED), and modulate ambient lighting to maintain the iris in a dilated, constricted, or mid-dilated position in real-time. Study participants underwent 3 consecutive 65-second scan sessions. Dynamic iris behavior in the form of peak constriction velocity (PCV) and mid-dilated iris activity (MDIA) were calculated and analyzed offline.
Among 58 participants, 56 (96.6%) were eligible for analysis based on achieving and maintaining mean PD within ±10% of the calculated mid-dilated PD. Mean participant age was 49.8 ± 18.9 years. Mean PCV was 3.92 ± 0.83 mm/s, and mean MDIA was 0.37 ± 0.15 mm. The mean difference between the calculated and achieved mid-dilated PD was 0.166 ± 0.192 mm. There were significant negative correlations between PCV and age (slope = -0.022, P < 0.001) and MDIA and age (slope = -0.004, P < 0.001). Success rates were lower (69.0%) but relationships between dynamic iris behavior and age were similar based on achieving and maintaining mean PD within ±5% of the calculated mid-dilated PD.
A programmable closed-loop iris control system can modulate dynamic iris behavior and maintain the iris in a mid-dilated position. Pupillary constriction velocity and iris activity in the mid-dilated position decrease with age.
This system can be applied to study dynamic disease processes involving the iris and establish novel biometric measures that could serve as risk factors for acute and chronic primary angle closure glaucoma (PACG).
本研究旨在开发和测试一种可编程闭环系统，用于跟踪、调节和评估动态虹膜行为，包括在中度扩张位置。
通过定制 ANTERION OCT 设备（德国海德堡工程公司）开发了一种可编程闭环虹膜控制系统。开发了定制软件来存储相机和光学相干断层扫描（OCT）图像，跟踪瞳孔直径（PD），控制发光二极管（LED），并实时调节环境照明以保持虹膜处于扩张、收缩或中度扩张位置。研究参与者进行了 3 次连续的 65 秒扫描。以峰值收缩速度（PCV）和中度扩张虹膜活动（MDIA）的形式计算和分析动态虹膜行为。
在 58 名参与者中，56 名（96.6%）根据达到并维持平均 PD 在计算的中度扩张 PD 的±10%内的标准进行了分析。参与者的平均年龄为 49.8±18.9 岁。平均 PCV 为 3.92±0.83mm/s，平均 MDIA 为 0.37±0.15mm。计算得出的与实际达到的中度扩张 PD 之间的平均差异为 0.166±0.192mm。PCV 与年龄呈显著负相关（斜率=-0.022，P<0.001），MDIA 与年龄呈显著负相关（斜率=-0.004，P<0.001）。基于将平均 PD 维持在计算的中度扩张 PD 的±5%内，成功率较低（69.0%），但动态虹膜行为与年龄之间的关系相似。
可编程闭环虹膜控制系统可以调节动态虹膜行为并维持虹膜处于中度扩张位置。瞳孔收缩速度和中度扩张位置的虹膜活动随年龄增长而降低。
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