University of Southern California Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Am J Ophthalmol. 2020 Dec;220:19-26. doi: 10.1016/j.ajo.2020.07.030. Epub 2020 Jul 28.
We sought to investigate anatomic mechanisms of angle narrowing by assessing ocular biometric determinants of anterior chamber angle width.
Population-based cross-sectional study.
Subjects ≥50 years of age from the Chinese American Eye Study underwent a comprehensive ocular examination, including anterior segment optical coherence tomography imaging and ultrasound A-scan. Independent variables, including anterior chamber depth (ACD), lens vault (LV), iris curvature (IC), anterior chamber width, lens thickness, vitreous cavity depth, and axial length, and dependent variables, including angle opening distance, were measured in 1 randomly selected eye per subject. Univariable and multivariable regression models with standardized regression coefficients (SRCs) and semipartial correlation coefficients squares (SPCC) were used to assess relative and unique contributions by independent variables to angle width.
Two thousand two hundred twenty-five subjects (1433 women and 834 men) were included in the analysis. All biometric parameters except lens thickness differed between men and women (age-adjusted P < .001). In model 1A (R = 0.66), which included ACD, lens thickness, and vitreous cavity depth, ACD (SRC = 0.64, SPCC = 0.19) and IC (SRC = -0.26, SPCC = 0.041) were the strongest determinants of angle opening distance. In model 1B (R = 0.58), which included LV and axial length, LV (SRC = -0.46, SPCC = 0.1) and IC (SRC = -0.3, SPCC = 0.047) were the strongest determinants of angle opening distance. Determinants of angle width were similar in separate multivariable models for men and women.
ACD, LV, and IC are the strongest determinants of angle width in Chinese Americans. Sex-related differences in angle width are explained by differences among biometric measurements. These results provide insights into anatomic mechanisms of angle narrowing and have important implications for quantitative assessments of angle closure eyes.
我们通过评估前房角宽度的眼部生物测量学决定因素来研究角度变窄的解剖机制。
基于人群的横断面研究。
参加中美眼研究的年龄≥50 岁的受试者接受了全面的眼部检查，包括眼前节光学相干断层扫描成像和超声 A 扫描。每个受试者随机选择一只眼测量独立变量，包括前房深度（ACD）、晶状体拱高（LV）、虹膜曲率（IC）、前房宽度、晶状体厚度、玻璃体腔深度和眼轴，以及依赖变量，包括房角开放距离。使用标准化回归系数（SRCs）和半偏相关系数平方（SPCC）的单变量和多变量回归模型来评估独立变量对角度宽度的相对和独特贡献。
共纳入 2225 名受试者（1433 名女性和 834 名男性）进行分析。除晶状体厚度外，所有生物测量参数在男性和女性之间均有差异（年龄调整后 P <.001）。在模型 1A（R=0.66）中，包括 ACD、晶状体厚度和玻璃体腔深度，ACD（SRC=0.64，SPCC=0.19）和 IC（SRC=-0.26，SPCC=0.041）是房角开放距离的最强决定因素。在模型 1B（R=0.58）中，包括 LV 和眼轴，LV（SRC=-0.46，SPCC=0.1）和 IC（SRC=-0.3，SPCC=0.047）是房角开放距离的最强决定因素。男性和女性的多变量模型中，角度宽度的决定因素相似。
在中国人中，ACD、LV 和 IC 是角度宽度的最强决定因素。角度宽度的性别差异由生物测量差异解释。这些结果提供了对角度变窄解剖机制的深入了解，并对定量评估闭角眼具有重要意义。
