From the Keck School of Medicine (J.L.), at the University of Southern California, Los Angeles, California, USA.
USC Roski Eye Institute, Department of Ophthalmology (B.B., X.J., A.A.P., G.R., R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Am J Ophthalmol. 2022 May;237:183-192. doi: 10.1016/j.ajo.2021.10.027. Epub 2021 Nov 2.
To assess ocular biometric determinants of dark-to-light change in anterior chamber angle width and identify dynamic risk factors in primary angle closure disease (PACD).
Population-based cross-sectional study.
Chinese American Eye Study (CHES) participants underwent anterior segment optical coherence tomography imaging in the dark and light. Static dark and light biometric parameters, including angle opening distance, 750 µm (AOD750), anterior chamber width (ACW), lens vault (LV), and pupillary diameter (PD) were measured, and dynamic dark-to-light changes were calculated. Contributions by static and dynamic parameters to dark-to-light changes in AOD750 were assessed using multivariable linear regression models with standardized regression coefficients (SRCs) and semipartial correlation coefficients squared (SPCC). PACD was defined as ≥3 quadrants of gonioscopic angle closure.
The analysis included 1011 participants. All biometric parameters differed between dark and light (P < .05). On multivariable regression analysis, change in ACW (SRC = -0.35, SPCC = 0.081) and PD (SRC = -0.46, SPCC = 0.072) were the strongest determinants of dark-to-light change in AOD750 (overall R = 0.40). Dark-to-light increase in AOD750 was less in eyes with than without PACD (0.081 mm and 0.111 mm, respectively; P < .001). ACW increased in eyes with PACD and decreased in eyes without PACD from dark to light (P < .025), whereas change in PD was similar (P = .28).
Beneficial angle widening effects of transitioning from dark to light are attenuated in eyes with PACD, which appears related to aberrant dark-to-light change in ACW. These findings highlight the importance of assessing the angle in both dark and light to identify potential dynamic mechanisms of angle closure.
评估眼前段光学相干断层扫描（OCT）在暗光和亮光下前房角宽度变化的眼部生物测量学决定因素，并确定原发性闭角型青光眼（PACG）的动态危险因素。
基于人群的横断面研究。
美国华裔眼研究（CHES）参与者在暗光和亮光下接受眼前段 OCT 成像。测量静态暗光和亮光生物测量参数，包括房角开放距离 750μm（AOD750）、前房宽度（ACW）、晶状体拱高（LV）和瞳孔直径（PD），并计算动态暗光-亮光变化。使用标准化回归系数（SRCs）和偏部分相关系数平方（SPCC）的多变量线性回归模型评估静态和动态参数对 AOD750 暗光-亮光变化的贡献。PACG 的定义为≥3 象限的房角关闭。
分析包括 1011 名参与者。暗光和亮光下所有生物测量参数均有差异（P <.05）。多变量回归分析显示，ACW 的变化（SRC = -0.35，SPCC = 0.081）和 PD 的变化（SRC = -0.46，SPCC = 0.072）是 AOD750 暗光-亮光变化的最强决定因素（总 R 2 = 0.40）。有和无 PACG 的眼 AOD750 的暗光-亮光增加量分别为 0.081mm 和 0.111mm（P <.001）。暗光到亮光时，PACG 眼的 ACW 增加，无 PACG 眼的 ACW 减少（P <.025），而 PD 的变化相似（P =.28）。
从暗光切换到亮光时，有益的角度增宽效应在 PACG 眼中减弱，这似乎与 ACW 的异常暗光-亮光变化有关。这些发现强调了在暗光和亮光下评估角度的重要性，以确定潜在的角度关闭的动态机制。
