Application of zeolites and zeolitic imidazolate frameworks in the biosensor development.

Biosensors are advanced devices for analysis of composition of blood, urine, environmental samples, and many other media. Their current development is tightly linked with nanomaterials, such as zeolites and zeolitic imidazolate framework (ZIFs). The present review describes electrochemical (amperometric, conductometric, ISFET) and optical (fluorescent and colorimetric) biosensors that incorporate zeolites and ZIFs in their biorecognition elements. The biosensors are based on immobilized enzymes (such as glucose oxidase, urease, and acetylcholinesterase), antibodies, DNA, and aptamers. The review present reasons for application of these nanomaterials, and discusses advantages of zeolite- and ZIF-containing biosensors over other biosensors. In most cases, the biosensors have improved sensitivity, better limit of detection, wider linear range, and other improved characteristics. It is demonstrated that immobilization of biomolecules such as enzymes or antibodies on the surface of zeolites and ZIFs enables creation of unique advanced biosensors that have a potential for further development and practical applications.