Department of Psychology, University of Miami, 5665 Ponce de Leon Blvd, Fifth Floor, Coral Gables, FL 33146, United States of America.
Department of Psychology, University of Miami, 5665 Ponce de Leon Blvd, Fifth Floor, Coral Gables, FL 33146, United States of America; Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Ave, Miami, FL 33136, United States of America.
Gen Hosp Psychiatry. 2022 Nov-Dec;79:128-134. doi: 10.1016/j.genhosppsych.2022.10.012. Epub 2022 Oct 27.
Targets of intervention in cognitive behavioral stress management (CBSM), such as benefit finding (BF) and perceived stress management skills (PSMS), may counteract stress-related changes that impact the immune system. This study tested whether BF, PSMS, and optimism influence the effects of CBSM on immune status in men with prostate cancer.
Men with prostate cancer were randomized to receive CBSM or a psychoeducation (PE) control comparison (NCT05486754). Life Orientation Test-Revised assessed baseline optimism. The Benefit Finding Scale and Measure of Current Status measured BF and PSMS after CBSM. T-cells and T-helper cells captured immune status change at baseline and 6-months post-CBSM. MPlus and SPSS (PROCESS) tested condition effects and moderated mediation, controlling for covariates.
256 primarily middle-aged, White Non-Hispanic or Hispanic men enrolled. PSMS mediated CBSM effects on T-cell and T-helper cell percentage, such that T-cell and T-helper cell percentages were reduced in men in CBSM versus PE via PSMS. Optimism moderated this mediation with the mediating effect of PSMS only observed among men with average optimism versus those with low or high optimism.
Baseline psychological characteristics, as well as limited specificity of immune measurement, could explain the conditional effects in this sample.
NCT05486754.
认知行为应激管理（CBSM）的干预目标，如获益发现（BF）和感知应激管理技能（PSMS），可能会抵消影响免疫系统的与应激相关的变化。本研究旨在测试 BF、PSMS 和乐观是否会影响 CBSM 对前列腺癌男性免疫状况的影响。
患有前列腺癌的男性被随机分配接受 CBSM 或心理教育（PE）对照比较（NCT05486754）。生活取向测试修订版评估了基线乐观程度。获益发现量表和当前状态量表测量了 CBSM 后的 BF 和 PSMS。T 细胞和 T 辅助细胞在基线和 CBSM 后 6 个月捕捉免疫状态变化。MPlus 和 SPSS（PROCESS）测试了条件效应和中介调节，控制了协变量。
共有 256 名主要为中年、白种非西班牙裔或西班牙裔男性参与了该研究。PSMS 介导了 CBSM 对 T 细胞和 T 辅助细胞百分比的影响，因此通过 PSMS，CBSM 组的 T 细胞和 T 辅助细胞百分比低于 PE 组。乐观程度调节了这种中介作用，只有在平均乐观程度的男性中，PSMS 的中介作用才会出现，而在低或高乐观程度的男性中则不会。
基线心理特征，以及免疫测量的有限特异性，可能会解释该样本中的条件效应。
NCT05486754。
