Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032.
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032; Department of Pediatrics, Columbia University Medical Center, New York, NY 10032.
Immunity. 2018 Feb 20;48(2):202-213. doi: 10.1016/j.immuni.2018.01.007.
Throughout life, T cells coordinate multiple aspects of adaptive immunity, including responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is studied in the context of a specific type of pathogen, antigen, or disease condition over a limited time frame, whereas in humans, T cells control multiple insults simultaneously throughout the body and maintain immune homeostasis over decades. In this review, we discuss how human T cells develop and provide essential immune protection at different life stages and highlight tissue localization and subset delineation as key determinants of the T cell functional role in immune responses. We also discuss how anatomic compartments undergo distinct age-associated changes in T cell subset composition and function over a lifetime. It is important to consider age and tissue influences on human T cells when developing targeted strategies to modulate T cell-mediated immunity in vaccines and immunotherapies.
在整个生命过程中，T 细胞协调适应性免疫的多个方面，包括对病原体、过敏原和肿瘤的反应。在小鼠模型中，T 细胞的作用是在特定类型的病原体、抗原或疾病条件下，在有限的时间内进行研究，而在人类中，T 细胞在整个身体中同时控制多种刺激，并在几十年内维持免疫稳态。在这篇综述中，我们讨论了人类 T 细胞如何在不同的生命阶段发育并提供必要的免疫保护，并强调组织定位和亚群划分是 T 细胞在免疫反应中功能作用的关键决定因素。我们还讨论了在一生中，解剖隔室如何随着年龄的增长而发生 T 细胞亚群组成和功能的不同变化。在开发针对疫苗和免疫疗法中 T 细胞介导免疫的靶向策略时，考虑年龄和组织对人类 T 细胞的影响非常重要。
