Shen Shenghai, Deng Langrun, Du Yiheng, Gao Jingjing, Zhang Chuanhao, Wang Yueduo, Shen Zhewen, Li Yixuan, Chen Xiaowen, Chen Hao
SDU-ANU Joint Science College, Shandong University, NO.180 Wenhua West Road, Gao Strict, Weihai 264209, China.
Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Int J Pharm. 2022 Dec 15;629:122385. doi: 10.1016/j.ijpharm.2022.122385. Epub 2022 Nov 12.
Wound dressings can be applied over the wound sites to provide long-lasting wound management and improve wound healing. Biological wound dressings are superior to synthetic materials due to biodegradability and biocompatibility. These biomaterials have demonstrated huge potential in the field of wound dressings. Applying bibliometric analysis combined with results-based descriptions to characterize the research status, hotspots, and cutting-edge topics, this study is the first in-depth qualitative, quantitative, data-driven overview of biological wound dressings research in recent decades. Filtered data were used to construct co-citation, heatmaps, bi-clustering, strategy maps, and other analyses and visualization. The results show that research on biological wound dressings has progressed considerably in the last 5 years with extensive global collaboration. A clear knowledge base has been developed. Chitosan hydrogels, bacterial cellulose, active agents (silver nanoparticles, growth factors, curcumin, etc.), and electrospinning fibers stand out as research hotspots. The research frontiers include novel starting materials, precise and controlled release systems, and clinical and regenerative medicine applications. We interpreted an overview of the excavated topics and expected the findings here to provide a guide and inspire innovations for developing the next generation wound dressings.
伤口敷料可应用于伤口部位，以提供持久的伤口管理并促进伤口愈合。生物伤口敷料由于具有生物可降解性和生物相容性，优于合成材料。这些生物材料在伤口敷料领域已展现出巨大潜力。本研究采用文献计量分析并结合基于结果的描述来表征研究现状、热点和前沿主题，是近几十年来首次对生物伤口敷料研究进行的深入定性、定量、数据驱动的综述。利用筛选后的数据构建共被引分析、热图、双聚类分析、战略图等分析和可视化图表。结果表明，过去5年里，生物伤口敷料研究在广泛的全球合作下取得了显著进展。已形成了清晰的知识基础。壳聚糖水凝胶、细菌纤维素、活性剂（银纳米颗粒、生长因子、姜黄素等）和电纺纤维成为研究热点。研究前沿包括新型起始材料、精确可控释放系统以及临床和再生医学应用。我们解读了挖掘出的主题概述，并期望此处的研究结果能为开发下一代伤口敷料提供指导并激发创新。
