• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

载银纳米粒子/壳寡糖/聚乙烯醇纳米纤维作为伤口敷料的研究：一项临床前研究。

Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study.

机构信息

Department of Pharmacy, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China.

出版信息

Int J Nanomedicine. 2013;8:4131-45. doi: 10.2147/IJN.S51679. Epub 2013 Nov 1.

DOI:10.2147/IJN.S51679
PMID:24204142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3818021/
Abstract

In this study, a mixture of poly(vinyl alcohol) (PVA) and chitosan oligosaccharides (COS) was electrospun with silver nanoparticles (AgNPs) to produce fibrous mats for use in wound healing. The AgNPs were reduced by COS prior to electrospinning or Ag(+) was reduced via ultraviolet irradiation in nanofibers. The morphologies of the PVA/COS/AgNO3 and PVA/COS-AgNP nanofibers were analyzed by scanning electron microscopy. Formation of the AgNPs was investigated by field emission transmission electron microscopy, ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. We also evaluated the biocompatibility of the nanofibers, particularly their cytotoxicity to human skin fibroblasts and potential to cause primary skin irritation. The in vitro antibacterial activity and in vivo wound healing capacity of the nanofibers were also investigated. The nanofibers had a smooth surface with an average diameter of 130-192 nm. The diameters of the AgNPs were in the range of 15-22 nm. The nanofibers significantly inhibited growth of Escherichia coli and Staphylococcus aureus bacteria. PVA/COS-AgNP nanofibers accelerated the rate of wound healing over that of the control (gauze). The results of our in vitro and in vivo animal experiments suggest that PVA/COS-AgNP nanofibers should be of greater interest than PVA/COS/AgNO3 nanofibers for clinical use as a bioactive wound dressing.

摘要

在这项研究中，将聚乙烯醇（PVA）和壳寡糖（COS）的混合物与银纳米粒子（AgNPs）共纺制成纤维垫，用于伤口愈合。AgNPs 是在电纺丝之前通过 COS 还原的，或者通过纳米纤维中的紫外光照射还原为 Ag(+)。通过扫描电子显微镜分析了 PVA/COS/AgNO3 和 PVA/COS-AgNP 纳米纤维的形态。通过场发射透射电子显微镜、紫外-可见光谱、傅里叶变换红外光谱和 X 射线衍射研究了 AgNPs 的形成。我们还评估了纳米纤维的生物相容性，特别是它们对人皮肤成纤维细胞的细胞毒性和引起原发性皮肤刺激的潜力。还研究了纳米纤维的体外抗菌活性和体内伤口愈合能力。纳米纤维具有光滑的表面，平均直径为 130-192nm。AgNPs 的直径在 15-22nm 范围内。纳米纤维显著抑制了大肠杆菌和金黄色葡萄球菌的生长。与对照（纱布）相比，PVA/COS-AgNP 纳米纤维加速了伤口愈合的速度。我们的体外和体内动物实验结果表明，PVA/COS-AgNP 纳米纤维作为一种生物活性伤口敷料，其临床应用价值应高于 PVA/COS/AgNO3 纳米纤维。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/d725d5b3b044/ijn-8-4131Fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/3e4b323e9712/ijn-8-4131Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/5d1dd3fde2dc/ijn-8-4131Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/18a25c4fec81/ijn-8-4131Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/605b9c7d5b50/ijn-8-4131Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/2b7e1fc494d4/ijn-8-4131Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/a4de33a4dcdf/ijn-8-4131Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/2b7e2c9a6f1c/ijn-8-4131Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/1cee15ea705b/ijn-8-4131Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/ab552c1111f7/ijn-8-4131Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/fbdd159fe6ce/ijn-8-4131Fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/505a512f33ab/ijn-8-4131Fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/9b5d64fdc603/ijn-8-4131Fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/190a4e02ada9/ijn-8-4131Fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/d725d5b3b044/ijn-8-4131Fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/3e4b323e9712/ijn-8-4131Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/5d1dd3fde2dc/ijn-8-4131Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/18a25c4fec81/ijn-8-4131Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/605b9c7d5b50/ijn-8-4131Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/2b7e1fc494d4/ijn-8-4131Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/a4de33a4dcdf/ijn-8-4131Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/2b7e2c9a6f1c/ijn-8-4131Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/1cee15ea705b/ijn-8-4131Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/ab552c1111f7/ijn-8-4131Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/fbdd159fe6ce/ijn-8-4131Fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/505a512f33ab/ijn-8-4131Fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/9b5d64fdc603/ijn-8-4131Fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/190a4e02ada9/ijn-8-4131Fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/3818021/d725d5b3b044/ijn-8-4131Fig14.jpg

相似文献

1
Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study.载银纳米粒子/壳寡糖/聚乙烯醇纳米纤维作为伤口敷料的研究：一项临床前研究。
Int J Nanomedicine. 2013;8:4131-45. doi: 10.2147/IJN.S51679. Epub 2013 Nov 1.
2
The Cellular and Molecular Mechanisms Underlying Silver Nanoparticle/Chitosan Oligosaccharide/Poly(vinyl alcohol) Nanofiber-Mediated Wound Healing.银纳米颗粒/壳寡糖/聚乙烯醇纳米纤维介导伤口愈合的细胞和分子机制
J Biomed Nanotechnol. 2017 Jan;13(1):17-34. doi: 10.1166/jbn.2017.2324.
3
Fabrication and durable antibacterial properties of electrospun chitosan nanofibers with silver nanoparticles.含银纳米颗粒的电纺壳聚糖纳米纤维的制备及其持久抗菌性能
Int J Biol Macromol. 2015 Aug;79:638-43. doi: 10.1016/j.ijbiomac.2015.05.058. Epub 2015 Jun 3.
4
Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing.具有抗菌和抗氧化性能的新型电纺壳聚糖/聚乙烯醇/氧化锌纳米纤维垫，可用于糖尿病伤口愈合。
Int J Biol Macromol. 2018 Dec;120(Pt A):385-393. doi: 10.1016/j.ijbiomac.2018.08.057. Epub 2018 Aug 12.
5
Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFβ1/Smad signaling pathway.银纳米颗粒/壳寡糖/聚乙烯醇纳米纤维通过激活TGFβ1/Smad信号通路促进伤口愈合。
Int J Nanomedicine. 2016 Jan 21;11:373-86. doi: 10.2147/IJN.S91975. eCollection 2016.
6
Silver Nanoparticle-Anchored Human Hair Kerateine/PEO/PVA Nanofibers for Antibacterial Application and Cell Proliferation.载银纳米粒子的人发角蛋白/PEO/PVA 纳米纤维的抗菌应用和细胞增殖性能
Molecules. 2021 May 8;26(9):2783. doi: 10.3390/molecules26092783.
7
Designing New Antibacterial Wound Dressings: Development of a Dual Layer Cotton Material Coated with Poly(Vinyl Alcohol)_Chitosan Nanofibers Incorporating L. Extract.设计新型抗菌伤口敷料：聚（乙烯醇）-壳聚糖纳米纤维双层涂覆棉材料的开发，其中包含 L. 提取物。
Molecules. 2020 Dec 27;26(1):83. doi: 10.3390/molecules26010083.
8
Electrospun chitosan nanofibers with controlled levels of silver nanoparticles. Preparation, characterization and antibacterial activity.静电纺丝壳聚糖纳米纤维，具有可控水平的银纳米粒子。制备、表征及抗菌活性。
Carbohydr Polym. 2014 Oct 13;111:530-7. doi: 10.1016/j.carbpol.2014.04.026. Epub 2014 Apr 20.
9
Synthesis of silver/FeO@chitosan@polyvinyl alcohol magnetic nanoparticles as an antibacterial agent for accelerating wound healing.银/FeO@壳聚糖@聚乙烯醇磁性纳米粒子的合成作为一种抗菌剂，可加速伤口愈合。
Int J Biol Macromol. 2022 Nov 30;221:1404-1414. doi: 10.1016/j.ijbiomac.2022.09.030. Epub 2022 Sep 9.
10
Silver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits.载银纳米粒子壳聚糖-PEG 水凝胶促进糖尿病诱导兔伤口愈合。
Int J Pharm. 2019 Mar 25;559:23-36. doi: 10.1016/j.ijpharm.2019.01.019. Epub 2019 Jan 19.

引用本文的文献

1
Polyacrylonitrile/Silver Nanoparticles Composite for Catalytic Dye Reduction and Real-Time Monitoring.用于催化染料还原及实时监测的聚丙烯腈/银纳米颗粒复合材料
Polymers (Basel). 2025 Jun 26;17(13):1762. doi: 10.3390/polym17131762.
2
Emerging nanomaterials for novel wound dressings: From metallic nanoparticles and MXene nanosheets to metal-organic frameworks.用于新型伤口敷料的新兴纳米材料：从金属纳米颗粒和MXene纳米片到金属有机框架。
Heliyon. 2024 Oct 22;10(21):e39611. doi: 10.1016/j.heliyon.2024.e39611. eCollection 2024 Nov 15.
3
SARS-CoV-2 Papain-like Protease Responsive ZnO/Daclatasvir-Loaded Chitosan/Gelatin Nanofibers as Smart Antimicrobial Medical Textiles: In Silico, In Vitro and Cell Studies.

本文引用的文献

1
Neomycin-loaded poly(styrene sulfonic acid-co-maleic acid) (PSSA-MA)/polyvinyl alcohol (PVA) ion exchange nanofibers for wound dressing materials.载新霉素的聚苯乙烯磺酸-马来酸共聚物（PSSA-MA）/聚乙烯醇（PVA）离子交换纳米纤维，可用作伤口敷贴材料。
Int J Pharm. 2013 May 1;448(1):71-8. doi: 10.1016/j.ijpharm.2013.03.011. Epub 2013 Mar 16.
2
Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process.采用改进型同轴静电纺丝工艺制备涂覆有银纳米颗粒的聚丙烯腈纳米纤维。
Int J Nanomedicine. 2012;7:5725-32. doi: 10.2147/IJN.S37455. Epub 2012 Nov 12.
3
Synthesis and biological evaluation of chitin hydrogel/nano ZnO composite bandage as antibacterial wound dressing.
SARS-CoV-2木瓜样蛋白酶响应性负载齐多夫定/达卡他韦的壳聚糖/明胶纳米纤维作为智能抗菌医用纺织品：计算机模拟、体外和细胞研究
Pharmaceutics. 2023 Aug 2;15(8):2074. doi: 10.3390/pharmaceutics15082074.
4
Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis.静电纺丝壳聚糖纳米纤维对动物皮肤伤口的治疗作用：系统评价与荟萃分析。
Int J Pharm X. 2023 Mar 1;5:100175. doi: 10.1016/j.ijpx.2023.100175. eCollection 2023 Dec.
5
Design, development, in-vitro and in-vivo evaluation of polylactic acid-based multifunctional nanofibrous patches for efficient healing of diabetic wounds.基于聚乳酸的多功能纳米纤维贴片用于糖尿病伤口高效愈合的设计、开发、体外和体内评估
Sci Rep. 2023 Feb 24;13(1):3215. doi: 10.1038/s41598-023-29032-x.
6
Bioengineered Water-Responsive Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Hybrids for Wound Dressing and Skin Tissue Engineering Applications.用于伤口敷料和皮肤组织工程应用的生物工程水响应性羧甲基纤维素/聚乙烯醇水凝胶杂化材料
Gels. 2023 Feb 18;9(2):166. doi: 10.3390/gels9020166.
7
Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application.金属基纳米颗粒：抗菌机制与生物医学应用
Microorganisms. 2022 Sep 3;10(9):1778. doi: 10.3390/microorganisms10091778.
8
Application of chitosan-based nanoparticles in skin wound healing.壳聚糖基纳米颗粒在皮肤伤口愈合中的应用。
Asian J Pharm Sci. 2022 May;17(3):299-332. doi: 10.1016/j.ajps.2022.04.001. Epub 2022 Apr 25.
9
Cyanine-Doped Nanofiber Mats for Laser Tissue Bonding.用于激光组织粘合的菁掺杂纳米纤维垫
Nanomaterials (Basel). 2022 May 9;12(9):1613. doi: 10.3390/nano12091613.
10
Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.用于剖宫产术后协同增强体内愈合和伤口护理的双金属氧化物杂化纳米复合材料的新型制备
Int Wound J. 2022 Nov;19(7):1705-1716. doi: 10.1111/iwj.13771. Epub 2022 Mar 4.
壳聚糖水凝胶/纳米 ZnO 复合绷带的合成及抗菌性能评价
J Biomed Nanotechnol. 2012 Dec;8(6):891-900. doi: 10.1166/jbn.2012.1461.
4
Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax.基于银、结冷胶、PVA 和硼砂的抗菌伤口敷料的制备及性能表征。
Carbohydr Polym. 2012 Oct 15;90(3):1362-70. doi: 10.1016/j.carbpol.2012.07.005. Epub 2012 Jul 11.
5
Controlled synthesis and characterization of hollow flower-like silver nanostructures.控制合成及中空花状银纳米结构的特性研究。
Int J Nanomedicine. 2012;7:1543-50. doi: 10.2147/IJN.S26524. Epub 2012 Mar 21.
6
Lysozyme-loaded, electrospun chitosan-based nanofiber mats for wound healing.载溶菌酶的壳聚糖基纳米纤维膜用于伤口愈合。
Int J Pharm. 2012 May 10;427(2):379-84. doi: 10.1016/j.ijpharm.2012.02.010. Epub 2012 Feb 14.
7
Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver.载银钛酸钾纳米纤维的优化抗菌和抗增殖活性。
Int J Nanomedicine. 2011;6:1579-86. doi: 10.2147/IJN.S18765. Epub 2011 Aug 2.
8
Nano Ag loaded PVA nano-fibrous mats for skin applications.载纳米银的 PVA 纳米纤维垫，用于皮肤应用。
J Biomed Mater Res B Appl Biomater. 2011 Feb;96(2):225-33. doi: 10.1002/jbm.b.31756. Epub 2010 Nov 17.
9
Development of novel chitin/nanosilver composite scaffolds for wound dressing applications.新型壳聚糖/纳米银复合支架的制备及其在创伤敷料中的应用。
J Mater Sci Mater Med. 2010 Feb;21(2):807-13. doi: 10.1007/s10856-009-3877-z. Epub 2009 Oct 3.
10
Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications.用于伤口敷料应用的超支化聚甘油电纺纳米纤维。
Acta Biomater. 2010 Mar;6(3):1069-78. doi: 10.1016/j.actbio.2009.09.018. Epub 2009 Sep 27.