Animal and Veterinary Services Program, University of Hawaii, Honolulu, Hawaii;, Email:
Human Nutrition Food and Animal Sciences, University of Hawaii, Honolulu, Hawaii.
J Am Assoc Lab Anim Sci. 2022 Nov 1;61(6):611-614. doi: 10.30802/AALAS-JAALAS-22-000047. Epub 2022 Nov 14.
Differences in cage microenvironments may contribute to variation in data and affect the outcome of animal studies involving metabolic diseases. To study this, we compared the effects 3 types of bedding-corncob bedding, hardwood bedding, and hardwood bedding plus a cardboard enrichment item-on baseline fasting and nonfasting blood glucose and body weight in mice. Mice housed on corncob bedding showed significantly higher fasting blood glucose than did mice housed on hardwood bedding, with or without the enrichment item. None of the groups showed an effect of bedding type on nonfasting blood glucose levels or body weight. This information informs the choice of bedding substrates for studies that measure fasting blood glucose and potentially mitigates a variable that could confound research outcomes.
笼具微环境的差异可能导致数据的变化，并影响涉及代谢疾病的动物研究的结果。为了研究这一点，我们比较了 3 种垫料——玉米芯垫料、硬木垫料和硬木垫料加纸板丰容物——对小鼠基础空腹和非空腹血糖及体重的影响。玉米芯垫料组的小鼠空腹血糖显著高于硬木垫料组，无论是否有丰容物。各组的垫料类型对非空腹血糖水平或体重均无影响。这些信息为测量空腹血糖的研究选择垫料底物提供了依据，并可能减轻了一个可能混淆研究结果的变量。
