Bayne Kathryn
AAALAC International Frederick MD USA.
Animal Model Exp Med. 2018 Jul 28;1(2):82-90. doi: 10.1002/ame2.12015. eCollection 2018 Jun.
The provision of environmental enrichment to numerous species of laboratory animals is generally considered routine husbandry. However, mouse enrichment has proven to be very complex due to the often contradictory outcomes (animal health and welfare, variability in scientific data, etc.) associated with strain, age of the animal when enrichment is provided, gender of the animal, scientific use of the animal, and other housing attributes. While this has led to some suggesting that mice should not be provided enrichment, more recently opinion is trending toward acknowledging that enrichment actually normalizes the animal and data obtained from a mouse living in a barren environment are likely not to be representative or even reliable. This article offers an overview of the types of impact enrichment can have on various strains of mice and demonstrates that enrichment not only has a role in mouse husbandry, but also can lead to new areas of scientific enquiry in a number of different fields.
为众多实验动物提供环境富集通常被视为常规饲养管理。然而，由于与品系、提供富集时动物的年龄、动物性别、动物的科学用途以及其他饲养属性相关的结果往往相互矛盾（动物健康和福利、科学数据的变异性等），小鼠的富集已被证明非常复杂。虽然这导致一些人建议不应给小鼠提供富集，但最近的观点倾向于承认，富集实际上使动物正常化，并且从生活在贫瘠环境中的小鼠获得的数据可能不具有代表性甚至不可靠。本文概述了富集对各种品系小鼠可能产生的影响类型，并表明富集不仅在小鼠饲养管理中发挥作用，还可在许多不同领域引发新的科学探究领域。
