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里程碑系列研究:子宫癌及其缓解策略。

Landmark Series on Disparities: Uterine Cancer and Strategies for Mitigation.

机构信息

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.

Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.

出版信息

Ann Surg Oncol. 2023 Jan;30(1):48-57. doi: 10.1245/s10434-022-12765-w. Epub 2022 Nov 14.

DOI:10.1245/s10434-022-12765-w
PMID:36376567
Abstract

Longstanding racial disparities exist in uterine cancer. There is a growing body of literature documenting differences in the prevalence, diagnosis, treatment, and tumor characteristics of uterine cancer in Black women compared with White women that significantly contribute to the outcome disparity seen between the groups. This article seeks to provide an overview of racial disparities present in uterine cancer, with attention on Black women in the USA, as well as offer a review on the multifactorial etiology of the disparities described.

摘要

长期以来,子宫癌存在着种族差异。越来越多的文献记录了黑人和白人女性在子宫癌的患病率、诊断、治疗和肿瘤特征方面存在差异,这些差异显著导致了两组之间的结局差异。本文旨在概述子宫癌中存在的种族差异,重点关注美国的黑人女性,并对所描述的差异的多因素病因进行综述。

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1
Landmark Series on Disparities: Uterine Cancer and Strategies for Mitigation.里程碑系列研究:子宫癌及其缓解策略。
Ann Surg Oncol. 2023 Jan;30(1):48-57. doi: 10.1245/s10434-022-12765-w. Epub 2022 Nov 14.
2
Racial disparities in histopathologic characteristics of uterine cancer are present in older, not younger blacks in an equal-access environment.在同等获得医疗资源的环境下,老年黑人而非年轻黑人的子宫癌组织病理学特征存在种族差异。
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Uterine Cancer Rates Rising, Racial Disparities Found.子宫癌发病率上升,存在种族差异。
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Disparities in uterine cancer epidemiology, treatment, and survival among African Americans in the United States.美国非裔人群中子宫癌的流行病学、治疗和生存的差异。
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引用本文的文献

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Optimizing Mainstreaming of Genetic Testing in Parallel With Ovarian and Endometrial Cancer Tumor Testing: How Do We Maximize Our Impact?优化基因检测与卵巢癌和子宫内膜癌肿瘤检测并行的主流化:我们如何最大化我们的影响?
JCO Precis Oncol. 2024 Dec;8:e2400525. doi: 10.1200/PO-24-00525. Epub 2024 Dec 23.
2
Trends in endometrial cancer incidence in the United States by race/ethnicity and age of onset from 2000 to 2019.2000年至2019年美国按种族/族裔和发病年龄划分的子宫内膜癌发病率趋势。
Am J Epidemiol. 2025 Jan 8;194(1):103-113. doi: 10.1093/aje/kwae178.
3
Disease progression, survival, and molecular disparities in Black and White patients with endometrioid endometrial carcinoma in real-world registries and GOG/NRG oncology randomized phase III clinical trials.
真实世界注册研究和 GOG/NRG 肿瘤学随机 III 期临床试验中黑人和白人子宫内膜样子宫内膜癌患者的疾病进展、生存和分子差异。
Gynecol Oncol. 2024 Apr;183:103-114. doi: 10.1016/j.ygyno.2024.03.026. Epub 2024 Apr 8.
4
Approaches to developing de novo cancer population models to examine questions about cancer and race in bladder, gastric, and endometrial cancer and multiple myeloma: the Cancer Intervention and Surveillance Modeling Network incubator program.开发新的癌症人群模型的方法,以研究膀胱癌、胃癌、子宫内膜癌和多发性骨髓瘤中癌症和种族相关问题:癌症干预和监测建模网络孵化器计划。
J Natl Cancer Inst Monogr. 2023 Nov 8;2023(62):219-230. doi: 10.1093/jncimonographs/lgad021.
5
Pathogenic germline variants in patients with endometrial cancer of diverse ancestry.不同种系来源的子宫内膜癌患者中的致病性种系变异。
Cancer. 2024 Feb 15;130(4):576-587. doi: 10.1002/cncr.35071. Epub 2023 Oct 27.