2016 年至 2020 年期间，中国 15 个省、直辖市的猪圆环病毒 3 的流行病学和遗传特征。
Epidemiological and genetic characteristics of porcine circovirus 3 in 15 provinces and municipalities of China between 2016 and 2020.
机构信息
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, People's Republic of China.
The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan, 430070, Hubei Province, People's Republic of China.
出版信息
Virol J. 2022 Nov 14;19(1):187. doi: 10.1186/s12985-022-01893-0.
Porcine circovirus 3 (PCV3) is a newly emerging virus and has been found associated with porcine dermatitis and nephropathy syndrome in pigs. Compared with PCV2, research into PCV3 cap gene sequencing is deficient. To investigate the prevalence and genotype distribution of PCV3, we collected 1291 samples from 211 pig farms throughout 15 provinces and municipalities. 312 out of 1291 samples were tested positive by PCR. We further sequenced and analyzed 164 PCR-positive samples. The majority (61.8%) of isolates we sequenced belong to genotype PCV3c. PCV3c is also the dominant genotype in Hubei, Hunan, Hebei province and Chongqing city. We found 3 sites under positive selection and located in predicted epitope peptide, revealing that the pig's immunity may be a reason those sites are undergoing highly positive selection.
猪圆环病毒 3 型（PCV3）是一种新出现的病毒，已被发现与猪皮炎肾病综合征有关。与 PCV2 相比，对 PCV3 衣壳基因测序的研究还很缺乏。为了调查 PCV3 的流行情况和基因型分布，我们从 15 个省、直辖市的 211 个猪场采集了 1291 份样本。1291 份样本中有 312 份经 PCR 检测呈阳性。我们进一步对 164 份 PCR 阳性样本进行了测序和分析。我们测序的分离株中，大多数（61.8%）属于基因型 PCV3c。PCV3c 也是湖北省、湖南省、河北省和重庆市的主要基因型。我们发现了 3 个处于正选择下的位点，这些位点位于预测的抗原肽中，表明猪的免疫可能是这些位点受到高度正选择的原因。
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