Department of Dermatology, Combined Military Hospital, Bahawalpur Cantt, Pakistan.
Department of Pathology, Combined Military Hospital, Kharian, Pakistan.
J Coll Physicians Surg Pak. 2022 Nov;32(11):1398-1403. doi: 10.29271/jcpsp.2022.11.1398.
To determine the frequency and antibiotic susceptibility pattern of CA-MRSA in patients with uncomplicated skin and soft tissue infections reporting to the dermatology outpatient of a tertiary health care hospital.
A descriptive study.
Dermatology outpatient of a tertiary care hospital in Punjab province of Pakistan, from September 2020 to August 2021.
Patients of all age groups and both genders reporting during the study period with community-associated uncomplicated bacterial skin and soft tissue infections were enrolled in the study. Samples were collected from skin lesions and cultured on blood agar and MacConkey agar plates. Antimicrobial susceptibility testing using the modified Kirby Baur disc diffusion technique was performed.
A total of 157 patients were included in the study. Impetigo was most common infection (n=80, 51%), followed by Furunculosis (n=47, 29.9%). The frequency of MRSA isolates was 54.1% (n=85). MRSA was significantly more frequently isolated from patients with furunculous, carbuncle and cutaneous abscesses as compared to impetigo. All MRSA isolates were sensitive to linezolid, teicoplanin, and vancomycin. 97.6%, 84.7%, and 72.9% of MRSA isolates were sensitive to rifampicin, minocycline, and fusidic acid respectively. 89.4% of MRSA were sensitive to amikacin and clindamycin. 63.5% were sensitive to doxycycline and 58.8% were sensitive to co-trimoxazole. Only 20% of MRSA were sensitive to ciprofloxacin.
The antibiotics active against CA-MRSA including rifampicin, minocycline, amikacin, and clindamycin may be used empirically in patients with furunculosis, cutaneous abscess, and carbuncles. Linezolid, teicoplanin, and vancomycin should be reserved for severe infections.
Uncomplicated skin and soft tissue infections, Community-associated Methicillin-resistant staphylococcus aureus (CA-MRSA), Antibiotic susceptibility pattern.
确定报告给三级保健医院皮肤科门诊的单纯性皮肤和软组织感染患者中社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）的频率和抗生素药敏模式。
描述性研究。
巴基斯坦旁遮普省三级保健医院的皮肤科门诊，时间为 2020 年 9 月至 2021 年 8 月。
研究期间，所有年龄组和性别报告的患有社区相关性单纯性细菌性皮肤和软组织感染的患者均被纳入研究。从皮肤病变处采集样本并接种于血琼脂和麦康凯琼脂平板上。采用改良 Kirby-Bauer 纸片扩散法进行抗生素药敏试验。
共纳入 157 例患者。脓疱病是最常见的感染（n=80，51%），其次是疖（n=47，29.9%）。MRSA 分离株的频率为 54.1%（n=85）。与脓疱病相比，MRSA 从疖肿、痈和皮肤脓肿患者中分离的频率明显更高。所有 MRSA 分离株均对利奈唑胺、替考拉宁和万古霉素敏感。MRSA 分离株对利福平、米诺环素和夫西地酸的敏感性分别为 97.6%、84.7%和 72.9%。89.4%的 MRSA 对阿米卡星敏感，84.7%对克林霉素敏感。63.5%对多西环素敏感，58.8%对复方磺胺甲噁唑敏感。只有 20%的 MRSA 对环丙沙星敏感。
针对 CA-MRSA 的抗生素，包括利福平、米诺环素、阿米卡星和克林霉素，可在疖肿、皮肤脓肿和痈患者中经验性使用。对于严重感染，应保留利奈唑胺、替考拉宁和万古霉素。
单纯性皮肤和软组织感染，社区相关性耐甲氧西林金黄色葡萄球菌（CA-MRSA），抗生素药敏模式。
