School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China.
Analyst. 2022 Dec 5;147(24):5655-5662. doi: 10.1039/d2an01538b.
Metal-organic frameworks (MOFs) have emerged as interesting nanomaterials owing to their large surface area, high porosity, tunable pore architecture and easy functionalization. However, an inferior electrical conductivity hinders their application in electrochemical sensing. In this paper, gold-palladium alloy/UiO-66-NH/graphene (AuPd/UiO-66-NH/GN) composites were synthesized by loading alloys on the surfaces of MOFs and then attaching them to the graphene surface. The addition of metal nanoparticles and graphene enhanced the electron transfer ability of MOFs. Then, composites were used to modify a glassy carbon electrode (GCE) to construct a sensitive dopamine (DA) electrochemical sensor. The developed sensor manifested two linear relationships in lower concentration ranges and in higher concentration ranges with a 0.21 × 10 mol L low detection limit (3/) under optimal conditions. The results certified that the constructed sensor had high selectivity, excellent reproducibility and good stability, and had been used successfully for DA detection in actual human serum samples.
金属-有机骨架（MOFs）由于其大的表面积、高的孔隙率、可调的孔结构和易于功能化而成为有趣的纳米材料。然而，较差的导电性阻碍了它们在电化学传感中的应用。在本文中，通过将合金负载在 MOFs 的表面上，然后将其附着在石墨烯表面上，合成了金钯合金/UiO-66-NH/石墨烯（AuPd/UiO-66-NH/GN）复合材料。金属纳米粒子和石墨烯的添加增强了 MOFs 的电子传递能力。然后，将复合材料用于修饰玻碳电极（GCE），以构建灵敏的多巴胺（DA）电化学传感器。在最佳条件下，所开发的传感器在较低浓度范围和较高浓度范围均表现出两个线性关系，检测限低至 0.21×10mol L（3/）。结果证明，所构建的传感器具有高选择性、优异的重现性和良好的稳定性，并已成功用于实际人血清样品中 DA 的检测。
