基于金纳米粒子沉积氧化石墨烯上自组装混合表面活性剂的超分子电化学多巴胺传感器。

Supramolecular Electrochemical Sensor for Dopamine Detection Based on Self-Assembled Mixed Surfactants on Gold Nanoparticles Deposited Graphene Oxide.

机构信息

Department of Applied Physics, Faculty of Engineering, Rajamangala University of Technology Isan, Khon Kaen Campus, Khon Kaen 40000, Thailand.

Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

出版信息

Molecules. 2020 May 29;25(11):2528. doi: 10.3390/molecules25112528.

A new supramolecular electrochemical sensor for highly sensitive detection of dopamine (DA) was fabricated based on supramolecular assemblies of mixed two surfactants, tetra-butylammonium bromide (TBABr) and sodium dodecyl sulphate (SDS), on the electrodeposition of gold nanoparticles on graphene oxide modified on glassy carbon electrode (AuNPs/GO/GCE). Self-assembled mixed surfactants (TBABr/SDS) were added into the solution to increase the sensitivity for the detection of DA. All electrodes were characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The supramolecular electrochemical sensor (TBABr/SDS⋅⋅⋅AuNPs/GO/GCE) showed excellent electrocatalytic activity toward the oxidation of DA. Under the optimum conditions, the concentration of DA was obtained in the range from 0.02 µM to 1.00 µM, with a detection limit of 0.01 µM (3s/b). The results displayed that TBABr/SDS⋅⋅⋅AuNPs/GO/GCE exhibited excellent performance, good sensitivity, and reproducibility. In addition, the proposed supramolecular electrochemical sensor was successfully applied to determine DA in human serum samples with satisfactory recoveries (97.26% to 104.21%).

基于混合两亲分子在金纳米粒子修饰的氧化石墨烯修饰玻碳电极上电沉积组装，构建了一种用于高灵敏度检测多巴胺（DA）的新型超分子电化学传感器。自组装混合两亲分子（TBABr/SDS）被添加到溶液中，以提高检测 DA 的灵敏度。所有电极均通过扫描电子显微镜（SEM）、循环伏安法（CV）和电化学阻抗谱（EIS）进行了表征。超分子电化学传感器（TBABr/SDS⋅⋅⋅AuNPs/GO/GCE）对 DA 的氧化表现出优异的电催化活性。在最佳条件下，DA 的浓度在 0.02 μM 至 1.00 μM 的范围内获得，检测限为 0.01 μM（3s/b）。结果表明，TBABr/SDS⋅⋅⋅AuNPs/GO/GCE 表现出优异的性能、良好的灵敏度和重现性。此外，所提出的超分子电化学传感器成功应用于测定人血清样品中的 DA，回收率令人满意（97.26%至 104.21%）。