巴西产具有碳青霉烯酶 BKC-1 的临床分离菌属于铜绿假单胞菌的特征。
Characterization of a Carbapenem-Resistant BKC-1-Producing Clinical Isolate Belonging to the Pseudomonas putida Group from Brazil.
机构信息
Universidade Federal de São Paulo, Laboratório ALERTA, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil.
Universidade Federal de São Paulo, Laboratório de Imunologia e Bacteriologia, Setor de Biologia Molecular, Microbiologia e Imunologia, Departamento de Ciências Biológicas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Diadema, São Paulo, Brazil.
出版信息
Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0083922. doi: 10.1128/aac.00839-22. Epub 2022 Nov 15.
Since its first report, the class A Brazilian Klebsiella carbapenemase (BKC) has been detected only among isolates from Brazilian hospitals. In this study, we characterized a multidrug-resistant Pseudomonas juntendi clinical isolate and identified a 43.3-kb plasmid carrying and a class 1 integron (In) containing the , , , and gene cassettes. Our results confirm the ability of Pseudomonas putida group isolates to acquire antimicrobial resistance determinants and further act as resistance reservoirs.
自首次报告以来，A 类巴西产碳青霉烯酶（BKC）仅在巴西医院的分离株中检测到。在本研究中，我们对一株多药耐药性的假性洋葱伯克霍尔德菌临床分离株进行了特征描述，并鉴定出一个 43.3kb 的质粒，该质粒携带 和一个含有 、 、 和 基因盒的 1 类整合子（In）。我们的结果证实了假单胞菌属分离株获得抗微生物药物耐药决定因子的能力，并进一步充当耐药储存库。
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