Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives UMR 5293, CNRS, CEA, University of Bordeaux, Bordeaux, France.
Brain Connectivity and Behaviour Laboratory, Sorbonne University, Paris, France.
Science. 2022 Nov 4;378(6619):505-510. doi: 10.1126/science.abq2591. Epub 2022 Nov 3.
There is more to brain connections than the mere transfer of signals between brain regions. Behavior and cognition emerge through cortical area interaction. This requires integration between local and distant areas orchestrated by densely connected networks. Brain connections determine the brain's functional organization. The imaging of connections in the living brain has provided an opportunity to identify the driving factors behind the neurobiology of cognition. Connectivity differences between species and among humans have furthered the understanding of brain evolution and of diverging cognitive profiles. Brain pathologies amplify this variability through disconnections and, consequently, the disintegration of cognitive functions. The prediction of long-term symptoms is now preferentially based on brain disconnections. This paradigm shift will reshape our brain maps and challenge current brain models.
脑连接不仅仅是脑区之间信号的简单传递。行为和认知是通过皮质区相互作用而产生的。这需要由密集连接的网络协调局部和远程区域之间的整合。脑连接决定了大脑的功能组织。活体脑连接的成像为确定认知神经生物学背后的驱动因素提供了机会。物种间和人类间的连接差异进一步加深了对大脑进化和认知特征差异的理解。脑连接通过断开连接而放大了这种可变性，从而导致认知功能的瓦解。目前，对长期症状的预测更倾向于基于脑连接的断开。这种范式转变将重塑我们的脑图谱，并挑战当前的脑模型。
