Agrell U
Med Hypotheses. 1986 Jul;20(3):261-70. doi: 10.1016/0306-9877(86)90042-3.
A general stochastic theory of cancer is outlined by applying to cancer the laws of quantum mechanics instead of the laws of traditional physics, especially with regard to the concept of cause. This theory is combined with the evolutionary theory on the one hand and the mutation theory of aging/death of multicellular beings consisting of somatic cells on the other. The cancer theory centers around the phenomenon of DNA mutating randomly by quantal steps. Because of mutations in the DNA in general as well as in the special DNA which codes for the DNA repairing systems the body is permeated in the course of time - via increasing losses of information in the DNA - with increasingly altered proteins which is observed as aging process. From this process of entropy the concept of the cancer cell is deduced: When the losses of information in a certain cell and also in the repairing and immunological systems have random concordances, cancer as a type of antigens comes into existence. Here the concept of CONCORDANCE OF "BLURRING" is introduced. This CONCORDANCE OF "BLURRING" occurs randomly approximately once among three times 60 000 billion cells, i.e. three human beings. The so-called "oncogenes" are integrated into this theory. It is proposed to test this theory using monozygotic twins both suffering from cancer: By injecting monoclonally multiplied immunological systems, eventually also repair-systems, from the respective other twin, the proposition is that the cancer would be cured in both twins. If this critical experiment is successful, one can cure human beings suffering from cancer by the same procedure, using those systems of their relatives. This treatment would cure the cancer to the extent to which there is a genetic correspondence in the sections of genes coding for these systems.
通过将量子力学定律而非传统物理学定律应用于癌症,尤其是在病因概念方面,概述了一种癌症的通用随机理论。该理论一方面与进化论相结合,另一方面与由体细胞组成的多细胞生物衰老/死亡的突变理论相结合。癌症理论围绕DNA以量子步骤随机突变的现象展开。由于一般DNA以及编码DNA修复系统的特殊DNA发生突变,随着时间的推移,身体会因DNA信息损失增加而充斥着越来越多改变的蛋白质,这一过程被视为衰老过程。从这个熵增过程中推导出癌细胞的概念:当某个细胞以及修复和免疫系统中的信息损失出现随机一致性时,作为一种抗原类型的癌症就会产生。这里引入了“模糊”一致性的概念。这种“模糊”一致性大约在三万次六千亿个细胞(即三个人)中随机出现一次。所谓的“癌基因”也被纳入该理论。建议使用患癌的同卵双胞胎来检验这一理论:通过注射来自各自另一个双胞胎单克隆扩增的免疫系统,最终也包括修复系统,推测癌症在两个双胞胎中都能被治愈。如果这个关键实验成功,就可以通过相同的程序,利用其亲属的这些系统治愈患癌的人类。这种治疗将在编码这些系统的基因部分存在基因对应关系的程度上治愈癌症。