Park Jee Won, Arah Onyebuchi A, Martinez-Maza Otoniel, Dobs Adrian S, Ho Ken S, Palella Frank J, Seaberg Eric C, Detels Roger
Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Int J Sex Health. 2022;34(3):462-473. doi: 10.1080/19317611.2022.2084200. Epub 2022 Jun 13.
Examine prospective relationships between erectile dysfunction (ED) drugs EDand CD4 and CD8 T-cells, and immune markers among men who have sex with men (MSM).
Data from Multicenter AIDS Cohort Study, an observational prospective cohort study, with semi-annual follow-ups conducted in four U.S. centers from 1998 onwards was used. Marginal structural models using g-computation was fitted to estimate the mean differences for the effects of self-reported ED drug use on CD4 and CD8 T-cell outcomes and immune biomarkers.
Total of 1,391 men with HIV (MWH) and 307 men without HIV (MWOH) was included. Baseline mean CD4 cell count among MWH and MWOH was 499.9 cells/μL and 966.7 cells/μL, respectively. At baseline, 41.8% of MWH were virally suppressed. ED drug users reported a mean of 44.4 months of exposure to ED drugs. ED drug use was associated with increased CD4 cell outcomes among MWH but not MWOH. Mean differences in CD4 cell counts after 1 year of ED drug use was 57.6 cells/μL and increased to 117.7 after 10 years among MWH. CD8 counts were higher in ED drug users among MWH over 10 years than non-users; no consistent differences were found among MWOH. ED drug use appeared to reduce immune marker levels, such as IL-6 and increase markers, such as IL-10. We observed similar effects of ED drug use on biomarker levels among MWOH.
Long-term use of ED drugs do not adversely affect immune function among MWH or MWOH. Future studies on the relationships between different types of ED drugs and effects on T-cell subtypes are warranted.
研究勃起功能障碍(ED)药物与男男性行为者(MSM)的CD4和CD8 T细胞及免疫标志物之间的前瞻性关系。
使用多中心艾滋病队列研究的数据,这是一项观察性前瞻性队列研究,自1998年起在美国四个中心进行半年一次的随访。采用g计算的边际结构模型来估计自我报告的ED药物使用对CD4和CD8 T细胞结果及免疫生物标志物影响的平均差异。
共纳入1391名感染HIV的男性(MWH)和307名未感染HIV的男性(MWOH)。MWH和MWOH的基线平均CD4细胞计数分别为499.9个细胞/μL和966.7个细胞/μL。基线时,41.8%的MWH病毒得到抑制。ED药物使用者报告平均接触ED药物44.4个月。ED药物使用与MWH的CD4细胞结果增加有关,但与MWOH无关。MWH使用ED药物1年后CD4细胞计数的平均差异为57.6个细胞/μL,并在10年后增加到117.7个细胞/μL。10年以上,MWH中使用ED药物者的CD8计数高于未使用者;MWOH中未发现一致差异。ED药物使用似乎会降低免疫标志物水平,如IL-6,并增加标志物水平,如IL-10。我们在MWOH中观察到ED药物使用对生物标志物水平有类似影响。
长期使用ED药物对MWH或MWOH的免疫功能没有不利影响。有必要对不同类型的ED药物与对T细胞亚型的影响之间的关系进行进一步研究。