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替米沙坦诱发的血管性水肿:一种罕见的临床发现。

Telmisartan-induced angioedema: A rare clinical finding.

作者信息

Kumar Nitesh, Kiran Madhu, Gupta Kapil, Pareek Shatrughan

机构信息

Department of Emergency Medicine, AIIMS Jodhpur, Rajasthan, India.

Department of Emergency Medicine, Shantiram Medical College and Hospital, Andhra Pradesh, India.

出版信息

J Family Med Prim Care. 2022 Jul;11(7):4026-4028. doi: 10.4103/jfmpc.jfmpc_1710_21. Epub 2022 Jul 22.

DOI:10.4103/jfmpc.jfmpc_1710_21
PMID:36387724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9648316/
Abstract

Angioedema is swelling that mostly involves the soft tissue of the eyelids, nose, throat, tongue, mouth, or genitals. Angiotensin converting enzyme inhibitors induced angioedema is a rare but potentially dangerous adverse effect. A 52-year-old female patient attended the emergency department with the history swelling over the eyes and face past 3 days and having difficulty in swallowing of the food. Her medical history revealed that the patient was recently diagnosed with hypertension and was on the combination of Telmisartan and Amlodipin (40 mg + 5 mg). The medicines were immediately stopped and the patient was managed symptomatically for angioedema. The symptoms declined after 5 days of discontinuity of medicines. The case report can be considered as rare adverse effects of the Telmisartan. Angiotensin receptor blockers induced angioedema is a rare presentation.

摘要

血管性水肿是一种肿胀,主要累及眼睑、鼻子、喉咙、舌头、口腔或生殖器的软组织。血管紧张素转换酶抑制剂诱发的血管性水肿是一种罕见但潜在危险的不良反应。一名52岁女性患者因过去3天眼睛和面部肿胀且吞咽食物困难前往急诊科就诊。她的病史显示该患者最近被诊断为高血压,正在服用替米沙坦和氨氯地平(40毫克 + 5毫克)的组合药物。立即停用这些药物,并对该患者的血管性水肿进行对症治疗。停药5天后症状减轻。该病例报告可被视为替米沙坦罕见的不良反应。血管紧张素受体阻滞剂诱发的血管性水肿是一种罕见的表现。

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本文引用的文献

1
ACE inhibitor-mediated angioedema.血管紧张素转换酶抑制剂相关性血管水肿。
Int Immunopharmacol. 2020 Jan;78:106081. doi: 10.1016/j.intimp.2019.106081. Epub 2019 Dec 10.
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Clinical experiences and case review of angiotensin II receptor blocker-related angioedema in Korea.韩国血管紧张素 II 受体阻滞剂相关血管性水肿的临床经验和病例回顾。
Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):115-122. doi: 10.1111/bcpt.13097. Epub 2018 Aug 20.
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Cardiovascular drugs-induced oral toxicities: A murky area to be revisited and illuminated.心血管药物引起的口腔毒性:一个有待重新审视和阐明的模糊领域。
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Angioedema due to fixed dose combination of telmisartan plus ramipril.替米沙坦与雷米普利固定剂量复方制剂所致血管性水肿
J Pharmacol Pharmacother. 2014 Jul;5(3):214-6. doi: 10.4103/0976-500X.136113.
5
Incidence of adverse events with telmisartan compared with ACE inhibitors: evidence from a pooled analysis of clinical trials.替米沙坦与血管紧张素转换酶抑制剂相比的不良事件发生率:来自临床试验汇总分析的证据。
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