Delayed onset of angioedema with angiotensin-converting enzyme inhibitors: case report and review of the literature.

The angiotensin-converting enzyme inhibitors have gained widespread application in the management of hypertension and congestive heart failure, and after myocardial infarction. They are generally considered safe drugs, but there are a number of reports of angioedema associated with their use. In general, angioedema occurs within hours to days after initiation of therapy, and only a limited number of reports document a delayed onset. Our patient experienced angioedema after 14 months of therapy with benazepril.