Slattery Brian J, Sabherwal Sophie, O'Connor William T
Graduate Entry Medical School, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland.
BMJ Open Sci. 2022 Oct 17;6(1):e100276. doi: 10.1136/bmjos-2022-100276. eCollection 2022.
Primary polydipsia most commonly affects those with schizophrenia. The pathophysiology of this occurrence is not established. The aim of this systematic review is to critically assess the internal and external validity of the preclinical animal models available.
PubMed and Embase will be searched systematically to identify all relevant animal studies that describe polydipsia induction with a basis in schizophrenia aetiology. The SYRCLE (SYstematic Review Center for Laboratory animal Experimentation) search filters to identify all animal studies in both databases will be used. All studies published up to the date of the search will be considered.
Two independent reviewers will screen the retrieved studies for eligibility based on (1) title and abstract and (2) full text. Disagreements between researchers will be resolved by discussion and referral back to the predefined eligibility criteria with involvement of a third researcher if required.
原发性烦渴最常影响精神分裂症患者。这种情况的病理生理学尚未明确。本系统评价的目的是严格评估现有临床前动物模型的内部和外部有效性。
将系统检索PubMed和Embase，以识别所有基于精神分裂症病因描述烦渴诱导的相关动物研究。将使用SYRCLE（实验动物实验系统评价中心）检索过滤器来识别两个数据库中的所有动物研究。将考虑截至检索日期发表的所有研究。
两名独立的评审员将基于（1）标题和摘要以及（2）全文筛选检索到的研究是否符合纳入标准。研究人员之间的分歧将通过讨论解决，如有需要，将在第三位研究人员的参与下参照预先定义的纳入标准解决。
