Crouch Miranda, Quig Nathan, Yap Edward, Lau Winnie
Department of Neurology, University of North Carolina Hospitals, Chapel Hill, NC, United States.
Department of Neurosurgery, University of North Carolina Hospitals, Chapel Hill, NC, United States.
Front Neurol. 2022 Oct 28;13:952187. doi: 10.3389/fneur.2022.952187. eCollection 2022.
We report two cases of endovascular intervention for management of cerebral venous sinus thrombosis complicated by an acute intracranial hemorrhage during treatment with therapeutic anticoagulation. The first patient developed an acute subdural hematoma with progressive enlargement and was subsequently managed with venous sinus thrombectomy. The second patient developed an intraparenchymal and subdural hematoma and was treated with middle meningeal embolization. Anticoagulation is the primary treatment for cerebral venous sinus thrombosis but also contraindicated in an acute intracranial hemorrhage. In these cases, after endovascular intervention both patients resumed therapeutic anticoagulation without further hematoma expansion or additional invasive interventions. Both patients made an excellent neurological recovery and returned to their baseline functional independent status. Given the need for anticoagulation, endovascular intervention in the form of thrombectomy or middle meningeal artery embolization may be a viable adjuvant to anticoagulation in select patients.
我们报告了两例在治疗性抗凝治疗期间发生急性颅内出血并伴有脑静脉窦血栓形成的血管内介入治疗病例。首例患者出现急性硬膜下血肿且逐渐增大,随后接受了静脉窦血栓切除术。第二例患者出现脑实质内和硬膜下血肿,并接受了脑膜中动脉栓塞治疗。抗凝是脑静脉窦血栓形成的主要治疗方法,但在急性颅内出血时也属禁忌。在这些病例中,血管内介入治疗后,两名患者均恢复了治疗性抗凝,未出现血肿进一步扩大或额外的侵入性干预。两名患者均实现了出色的神经功能恢复,并恢复到基线功能独立状态。鉴于需要抗凝治疗,对于部分患者,血栓切除术或脑膜中动脉栓塞形式的血管内介入治疗可能是抗凝治疗的一种可行辅助手段。