Kim Jee Wook, Byun Min Soo, Yi Dahyun, Lee Jun Ho, Sung Kiyoung, Han Dongkyun, Byeon Gihwan, Kim Min Jung, Jung Joon Hyung, Chang Yoon Young, Jung Gijung, Lee Jun-Young, Lee Yun-Sang, Kim Yu Kyeong, Kang Koung Mi, Sohn Chul-Ho, Lee Dong Young
Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, 7 Keunjaebong-gil, Hwaseong, Gyeonggi 18450, Republic of Korea.
Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Gangwon 24252, Republic of Korea.
iScience. 2022 Oct 20;25(11):105422. doi: 10.1016/j.isci.2022.105422. eCollection 2022 Nov 18.
Little is known about the association between meal frequency and Alzheimer's disease (AD) in humans. We tested the hypothesis that low meal frequency (LMF) is associated with reduced AD pathology in human brain, and additionally investigated the mediation of serum ghrelin, a hunger-related hormone, for the association. A total of 411 non-demented older adults were systematically interviewed to identify their dietary patterns including meal frequency and underwent multi-modal neuroimaging for cerebral beta-amyloid (Aβ) and tau deposition, glucose metabolism, and cerebrovascular injury. LMF (less than three meals a day) was significantly associated with lower Aβ deposition compared to high meal frequency (HMF). In addition, both LMF and reduced Aβ deposition were significantly related to elevated serum ghrelin. Our findings suggest that LMF may be related to the lower risk of AD through reduced brain amyloid deposition. Additionally, ghrelin appears mediate the association between LMF and lower amyloid deposition.
关于人类进餐频率与阿尔茨海默病（AD）之间的关联，目前所知甚少。我们检验了这样一种假设，即低进餐频率（LMF）与人类大脑中AD病理变化的减轻有关，此外还研究了与饥饿相关的激素血清胃饥饿素在这种关联中的介导作用。我们对总共411名无痴呆的老年人进行了系统访谈，以确定他们的饮食模式，包括进餐频率，并对他们进行了多模态神经成像检查，以检测大脑中的β-淀粉样蛋白（Aβ）和tau蛋白沉积、葡萄糖代谢以及脑血管损伤情况。与高进餐频率（HMF）相比，低进餐频率（每天少于三餐）与较低的Aβ沉积显著相关。此外，低进餐频率和Aβ沉积减少均与血清胃饥饿素升高显著相关。我们的研究结果表明，低进餐频率可能通过减少脑淀粉样蛋白沉积而与较低的AD风险相关。此外，胃饥饿素似乎介导了低进餐频率与较低淀粉样蛋白沉积之间的关联。
