Sisay Eskinder Ayalew, Mengistu Bethlehem Lemma, Taye Workeabeba Abebe, Fentie Atalay Mulu, Yabeyu Abdella Birhan
Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
Department of Pediatrics and Child Health, Addis Ababa University, Addis Ababa, Ethiopia.
Int J Gen Med. 2022 Nov 9;15:8133-8142. doi: 10.2147/IJGM.S385829. eCollection 2022.
Sepsis is common among neonates, and is often fatal. Hospitalization results in severe nosocomial infections which could be resistant to antibiotics. It also incurs higher fees for medical care.
A retrospective follow-up study, which includes 206 neonates, was conducted to assess the length of hospital stay among neonatal sepsis patients from September 2018 to September 2020 at TASH Hospital, Addis Ababa, Ethiopia. Data were collected from medical charts. Mean length of hospital stay was compared using independent sample -tests. Risk factors for length of stay were identified using binary logistic regression analysis.
All neonates stayed a total of 325 days, which gives 75,512 neonate-days. Neonates who stayed more than 7 days had low mean birth weight and higher mean age at admission. Mean length of stay was higher among neonates with comorbid illness, neonates with drug therapy problems and male neonates. Even though the mean length of stay is shorter among neonates with maternal PROM and CS delivery, these maternal factors were found to be insignificant in the multivariate logistic regression.
Similar to other studies, neonates with low birth weight and comorbidity had a longer hospital stay. Neonates with maternal PROM and CS delivery had a shorter stay. But these maternal factors, identified by prior studies as risk factors for neonatal sepsis and its mortality, are not found to be predictors of prolonged hospitalization. Having neurologic features and drug therapy problems among neonates with sepsis prolonged hospital stay.
The mean length of stay varies with respect to maternal and neonatal factors. Lower birth weight, presence of neurologic features, presence of comorbidity, presence of drug therapy problems and being male are found to be predictors of a longer hospital stay among neonates with sepsis.
脓毒症在新生儿中很常见，且往往是致命的。住院会导致严重的医院感染，这些感染可能对抗生素耐药。这也会带来更高的医疗费用。
进行了一项回顾性随访研究，纳入206名新生儿，以评估2018年9月至2020年9月在埃塞俄比亚亚的斯亚贝巴塔什医院的新生儿脓毒症患者的住院时间。数据从病历中收集。使用独立样本t检验比较平均住院时间。使用二元逻辑回归分析确定住院时间的危险因素。
所有新生儿总共住院325天，即75512个新生儿日。住院超过7天的新生儿平均出生体重较低，入院时平均年龄较大。患有合并症的新生儿、有药物治疗问题的新生儿和男新生儿的平均住院时间较长。尽管胎膜早破和剖宫产分娩的新生儿平均住院时间较短，但在多变量逻辑回归中发现这些母体因素并不显著。
与其他研究相似，低出生体重和合并症的新生儿住院时间较长。胎膜早破和剖宫产分娩的新生儿住院时间较短。但这些先前研究确定为新生儿脓毒症及其死亡率危险因素的母体因素，并未被发现是延长住院时间的预测因素。脓毒症新生儿具有神经学特征和药物治疗问题会延长住院时间。
平均住院时间因母体和新生儿因素而异。低出生体重、存在神经学特征、存在合并症、存在药物治疗问题以及为男性被发现是脓毒症新生儿住院时间较长的预测因素。
