Gao Yalong, Li Kai, Li Xiaotian, Li Qifeng, Wang Jiwei, Zhang Shu, Zhang Jianning
Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
Front Neurosci. 2022 Oct 28;16:1013437. doi: 10.3389/fnins.2022.1013437. eCollection 2022.
Cerebral vasospasm is a frequently encountered clinical problem, especially in patients with traumatic brain injury and subarachnoid hemorrhage. Continued cerebral vasospasm can cause cerebral ischemia, even infarction and delayed ischemic neurologic deficits. It significantly affects the course of the disease and the outcome of the patient. However, the underlying mechanism of cerebral vasospasm is still unclear. Recently, increasing studies focus on the pathogenic mechanism of microparticles. It has been found that microparticles have a non-negligible role in promoting vasospasm. This research aims to summarize the dynamics of microparticles and identify a causal role of microparticles in the occurrence and development of cerebral vasospasm. We found that these various microparticles showed dynamic characteristics in body fluids and directly or indirectly affect the cerebral vasospasm or prompt it. Due to the different materials carried by microparticles from different cells, there are also differences in the mechanisms that lead to abnormal vasomotor. We suggest that microparticle scavengers might be a promising therapeutic target against microparticles associated complications.
脑血管痉挛是一个常见的临床问题，尤其是在创伤性脑损伤和蛛网膜下腔出血患者中。持续性脑血管痉挛可导致脑缺血，甚至梗死和迟发性缺血性神经功能缺损。它显著影响疾病进程和患者预后。然而，脑血管痉挛的潜在机制仍不清楚。近年来，越来越多的研究聚焦于微粒的致病机制。已发现微粒在促进血管痉挛方面具有不可忽视的作用。本研究旨在总结微粒的动态变化，并确定微粒在脑血管痉挛发生发展中的因果作用。我们发现，这些不同的微粒在体液中呈现动态特征，并直接或间接影响脑血管痉挛或促使其发生。由于来自不同细胞的微粒携带的物质不同，导致血管舒缩异常的机制也存在差异。我们认为，微粒清除剂可能是针对与微粒相关并发症的一个有前景的治疗靶点。
