Stone O J
Med Hypotheses. 1986 Aug;20(4):403-6. doi: 10.1016/0306-9877(86)90100-3.
A cyclical phenomenon of spurting polymorphonuclear leukocytes occurs in a number of skin diseases. The phenomenon is easy to observe because the polymorphonuclear leukocytes move into the epidermis and away from the vascular area. It is proposed that repeated spurting of polymorphonuclear leukocytes may be a broad biologic phenomenon. Edema appears essential to initiate the phenomenon by diluting the tissue fluids. The chemicals released by inflammation decrease ground substance viscosity and therefore interfere with dilution of tissue fluids. This stops the mediation of inflammation. The polymorphonuclear leukocytes also release connective tissue activating peptides which lead to increased glycosaminoglycans production and stimulate fibroblast to proliferate. The tissue activating peptides thus restore the viscosity of the ground substance and the cycle can be repeated. What we interpret as chronic inflammation could be the result of this repeated spurting phenomenon.
多形核白细胞的周期性喷出现象在多种皮肤病中出现。该现象易于观察，因为多形核白细胞会移入表皮并远离血管区域。有人提出，多形核白细胞的反复喷出可能是一种广泛的生物学现象。水肿似乎对于通过稀释组织液来启动该现象至关重要。炎症释放的化学物质会降低基质粘度，从而干扰组织液的稀释。这会阻止炎症的介导。多形核白细胞还会释放结缔组织激活肽，导致糖胺聚糖生成增加并刺激成纤维细胞增殖。组织激活肽从而恢复基质的粘度，并且该循环可以重复。我们所认为的慢性炎症可能就是这种反复喷出现象的结果。
