Hao Bin, Wei Li, Cheng Yusheng, Ma Zhifang, Wang Jingyu
Department of Urology, Central Hospital, China Railway 17th Bureau Group Co., Ltd., Shanxi, China.
Internal Medicine, Rongjun Hospital of Shanxi Province, Shanxi, China.
Front Bioeng Biotechnol. 2022 Nov 1;10:1046234. doi: 10.3389/fbioe.2022.1046234. eCollection 2022.
Prostate cancer (PC) has the second highest incidence in men, according to global statistical data. The symptoms of PC in the early stage are not obvious, causing late diagnosis in most patients, which is the cause for missing the optimal treatment time. Thus, highly sensitive and precise early diagnosis methods are very important. Additionally, precise therapy regimens for good targeting and innocuous to the body are indispensable to treat cancer. This review first introduced two diagnosis methods, containing prostate-specific biomarkers detection and molecular imaging. Then, it recommended advanced therapy approaches, such as chemotherapy, gene therapy, and therapeutic nanomaterial. Afterward, we summarized the development of nanomaterial in PC, highlighting the importance of integration of diagnosis and therapy as the future direction against cancer.
根据全球统计数据,前列腺癌(PC)在男性中的发病率位居第二。PC早期症状不明显,导致大多数患者确诊较晚,这也是错过最佳治疗时机的原因。因此,高灵敏度和精确的早期诊断方法非常重要。此外,针对癌症治疗,具有良好靶向性且对身体无害的精确治疗方案必不可少。本综述首先介绍了两种诊断方法,包括前列腺特异性生物标志物检测和分子成像。然后,推荐了先进的治疗方法,如化疗、基因治疗和治疗性纳米材料。之后,我们总结了纳米材料在PC治疗中的发展,强调了将诊断与治疗相结合作为未来抗癌方向的重要性。