First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
First Postdoctoral Department of Surgery, National and Kapodistrian University of Athens, Hippocration General Hospital, Athens, Greece.
Nutr Cancer. 2023;75(2):640-651. doi: 10.1080/01635581.2022.2146144. Epub 2022 Nov 17.
Oncologic patients often suffer from malnutrition, which might negatively affect treatment outcomes. Global Leadership Initiative on Malnutrition (GLIM)-based malnutrition is associated with short- and long-term outcomes in cancer patients. The aim of the current meta-analysis was to determine the impact of GLIM-defined malnutrition on postoperative complications and survival in esophageal and gastric cancer patients. A systematic search was conducted to identify studies published until February 2022 that assessed the association between GLIM criteria and short- and long-term outcomes in esophageal and gastric cancer patients. We included seven observational studies reporting on a total of 3662 patients with esophageal and gastric cancer. GLIM-defined malnutrition was associated with increased overall complications (pooled HR 2.58, 95% CI 1.45-4.59, = 0.001). Malnutrition was significantly associated with decreased overall survival (pooled HR 1.63, 95% CI 1.18-1.84, = 0.003) as well as with decreased disease-free survival (pooled HR 1.78, 95% CI 1.36-2.33, < 0.0001). GLIM-based malnutrition was associated with an increased risk for developing postoperative complications and impaired survival of esophageal and gastric cancer patients. Our findings support the use of GLIM criteria in clinical practice as a relatively simple and reliable tool for assessing the nutritional status of oncologic patients.
肿瘤患者常患有营养不良，这可能会对治疗结果产生负面影响。基于全球营养不良领导倡议 (GLIM) 的营养不良与癌症患者的短期和长期结局相关。本荟萃分析旨在确定 GLIM 定义的营养不良对食管和胃癌患者术后并发症和生存的影响。系统检索了截至 2022 年 2 月评估 GLIM 标准与食管和胃癌患者短期和长期结局之间关联的研究。我们纳入了 7 项观察性研究，共纳入 3662 例食管和胃癌患者。GLIM 定义的营养不良与总体并发症增加相关（合并 HR 2.58，95%CI 1.45-4.59， = 0.001）。营养不良与总生存时间缩短显著相关（合并 HR 1.63，95%CI 1.18-1.84， = 0.003），以及无病生存时间缩短显著相关（合并 HR 1.78，95%CI 1.36-2.33， < 0.0001）。基于 GLIM 的营养不良与术后并发症风险增加和食管和胃癌患者生存受损相关。我们的研究结果支持在临床实践中使用 GLIM 标准作为评估肿瘤患者营养状况的相对简单和可靠工具。
