[黑色素瘤微环境——现代疗法的影响]
[Melanoma microenvironment-impact of modern therapies].
作者信息
Sirokay Judith, Mauch Cornelia
机构信息
Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum Bonn, Gebäude 11, Venusberg-Campus 1, 53127, Bonn, Deutschland.
Klinik für Dermatologie und Venerologie, Universitätsklinikum Köln, Köln, Deutschland.
出版信息
Dermatologie (Heidelb). 2022 Dec;73(12):907-914. doi: 10.1007/s00105-022-05078-2. Epub 2022 Nov 17.
BACKGROUND
A considerable proportion of patients with advanced melanoma succumb to metastatic disease despite the initial success of modern therapies.
OBJECTIVES
An overview of the melanoma tumor microenvironment with special focus on approved therapies and new innovative strategies is given.
METHODS
Current clinical trials and scientific insights concerning the impact of the tumor microenvironment on progression and therapy of advanced melanoma are reviewed and discussed.
RESULTS
The tumor microenvironment with its manifold components and interactions plays a major role in the treatment of malignant melanoma.
CONCLUSION
Innovative new strategies that target an immunosuppressive microenvironment may improve the therapeutic efficacy of current treatment of advanced melanoma.
背景
尽管现代疗法取得了初步成功，但相当一部分晚期黑色素瘤患者仍死于转移性疾病。
目的
对黑色素瘤肿瘤微环境进行概述，特别关注已获批的疗法和新的创新策略。
方法
回顾并讨论了当前关于肿瘤微环境对晚期黑色素瘤进展和治疗影响的临床试验及科学见解。
结果
具有多种成分和相互作用的肿瘤微环境在恶性黑色素瘤的治疗中起着重要作用。
结论
针对免疫抑制微环境的创新新策略可能会提高当前晚期黑色素瘤治疗的疗效。
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