Department of Cardiology, IKEM, Vídeňská 1958/9, Prague 140 21, Czech Republic.
Department of Cardiology, IKEM, Vídeňská 1958/9, Prague 140 21, Czech Republic.
Card Electrophysiol Clin. 2022 Dec;14(4):779-792. doi: 10.1016/j.ccep.2022.06.010.
Stereotactic body radiotherapy is a recent promising therapeutic alternative in cases of failed catheter ablation for recurrent ventricular tachycardias (VTs) in patients with structural heart disease. Initial clinical experience with a single radiation dose of 25 Gy shows reasonable efficacy in the reduction of VT recurrences with acceptable acute toxicity. Many unanswered questions remain, including unknown mechanism of action, variable time to effect, optimal method of substrate targeting, long-term safety, and definition of an optimal candidate for this treatment."
立体定向体部放射治疗是结构性心脏病患者复发性室性心动过速（VT）导管消融失败后的一种有前途的治疗选择。单次 25Gy 放射剂量的初步临床经验显示，该方法在降低 VT 复发方面具有合理的疗效，且急性毒性可接受。目前仍有许多悬而未决的问题，包括作用机制不明、起效时间不同、最佳靶区确定方法、长期安全性以及这种治疗方法的最佳适应证选择。
