老年人精神药理学：为什么年龄很重要？

Psychopharmacology in the Elderly: Why Does Age Matter?

机构信息

Department of Psychiatry, MetroHealth Medical Center, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.

Northeast Ohio Medical University, Adult and Geriatric Psychiatry, Akron general-Cleveland Clinic, 1 Akron General Avenue, Akron, OH, 44307, USA.

出版信息

Psychiatr Clin North Am. 2022 Dec;45(4):735-744. doi: 10.1016/j.psc.2022.07.004. Epub 2022 Oct 14.

DOI:10.1016/j.psc.2022.07.004

PMID:36396276

Abstract

A growing percentage of the population is aging, with a large subset of this group meeting criteria for one or more neuropsychiatric disorders. Generally, physiological changes due to aging affect most of the pharmacokinetic processes in the body, with age-related physiologic changes in cardiovascular, gastric, hepatic, and renal function leading to changes in the pharmacokinetics of medications that can affect the absorption, distribution, accumulation, and clearance and elimination of various medications. This article aims to discuss the common pharmacodynamic and pharmacokinetic changes associated with physiologic aging and their impacts on the use of psychotropic medications in the elderly.

摘要

人口老龄化的比例不断增加，其中很大一部分人群符合一种或多种神经精神障碍的标准。一般来说，衰老引起的生理变化会影响体内大多数药代动力学过程，心血管、胃、肝和肾功能的衰老相关生理变化导致药物的药代动力学发生变化，从而影响各种药物的吸收、分布、蓄积和清除及消除。本文旨在讨论与生理衰老相关的常见药效学和药代动力学变化及其对老年人使用精神药物的影响。