Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Center for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), Charleroi (Gosselies), Belgium.
Nat Commun. 2022 Nov 17;13(1):7057. doi: 10.1038/s41467-022-34776-7.
The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of concept for future therapeutic development.
甲状腺通过摄取碘来合成作用于几乎所有组织的激素，这些激素对正常生长和代谢至关重要。甲状腺激素的血浆水平低会导致甲状腺功能减退症，这是人类最常见的疾病之一，而且终身激素替代治疗并不总是能令人满意。因此，除了缺乏体外可处理的模型来研究人类甲状腺的发育、分化和成熟外，功能性人类甲状腺类器官可能为探索新的治疗方法铺平道路。在这里，我们报告了从人类胚胎干细胞中产生可移植的甲状腺类器官的方法，这些类器官能够恢复甲状腺切除小鼠的血浆甲状腺激素，作为未来治疗开发的概念验证。
Zotero 插件
