Chuna Manual Medicine Research Group, College of Korean Medicine, Won-Kwang University, Iksan, Republic of Korea.
Department of Rehabilitation Medicine of Korean Medicine, Iksan-Jeil Korean Medicine Hospital, Iksan, Republic of Korea.
Medicine (Baltimore). 2022 Nov 11;101(45):e31311. doi: 10.1097/MD.0000000000031311.
Kyung-ok-ko (KOK), a traditional medicinal formula in East Asia, has been recently studied across various fields. However, comprehensive reviews of clinical applications of KOK targeting clinical and experimental studies are lacking. Therefore, the application of KOK is being limited to the range of tonic medicines. To overcome this limitation, we aim to investigate the effectiveness, mechanism, and safety of KOK to obtain evidence regarding its effects in clinical applications. We searched for clinical and experimental articles in 11 databases (PubMed, Cochrane Library, Excerpta Medica dataBASE, China National Knowledge Infrastructure, Google Scholar, Research Information Sharing Service, Oriental Medicine Advanced Searching Integrated System, Koreanstudies Information Service System, Korean Medical Database, DBpia, and ScienceON). We selected 54 studies based on the inclusion criteria. Three clinical studies used KOK for a consumptive disease and health promotion. Fifty-one experimental studies reported the antioxidant activity, neuroprotective activity, anticancer effect, anti-inflammatory activity, immunological activity, growth promotion, impacts on cardiovascular system diseases, gastrointestinal system diseases, respiratory system diseases, and metabolic bone disease, hepatoprotective function, and antifatigue function of KOK, which were considered effective and safe in consumptive, chronic, metabolic, inflammatory, and immune diseases. We identified the effectiveness of KOK in the treatment of a wide range of diseases. However, further clinical studies are warranted in the future.
韩国高丽参（KOK）是东亚的一种传统药物配方，近年来在多个领域得到了研究。然而，针对临床和实验研究，缺乏对 KOK 临床应用的综合综述。因此，KOK 的应用仅限于滋补药物的范围。为了克服这一局限性，我们旨在研究 KOK 的有效性、机制和安全性，以获得其在临床应用中的效果证据。我们在 11 个数据库（PubMed、Cochrane Library、Excerpta Medica dataBASE、中国国家知识基础设施、Google Scholar、研究信息共享服务、东方医学高级搜索集成系统、韩国研究信息服务系统、韩国医学数据库、DBpia 和 ScienceON）中搜索了临床和实验文章。我们根据纳入标准选择了 54 项研究。三项临床研究使用 KOK 治疗消耗性疾病和促进健康。五十一项实验研究报告了 KOK 的抗氧化活性、神经保护活性、抗癌作用、抗炎活性、免疫活性、促生长作用、对心血管系统疾病、胃肠道系统疾病、呼吸系统疾病和代谢性骨疾病的影响、肝保护功能和抗疲劳功能，这些在消耗性、慢性、代谢性、炎症性和免疫性疾病中被认为是有效和安全的。我们确定了 KOK 在治疗广泛疾病方面的有效性。然而，未来仍需要进一步的临床研究。
