Advanced Regional Research Center in Gastroenterology and Hepatology, Department VII: Internal Medicine II, Discipline of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Romania.
Center for Modeling Biological Systems and Data Analysis, Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy Timisoara, Romania.
Medicine (Baltimore). 2022 Nov 11;101(45):e31543. doi: 10.1097/MD.0000000000031543.
Acute upper gastrointestinal bleeding (UGIB) is a typical medical emergency, with an incidence of 84 to 160 cases per 100,000 individuals and a mortality rate of approximately 10%. This study aimed to identify all cases of UGIB hospitalized in a tertiary gastroenterology department, to identify possible predictive factors involved in rebleeding and mortality, potential associations between different elements and the severity of bleeding, and the differences between the upper digestive hemorrhage due to nonvariceal and variceal bleeding. This was an observational, retrospective study of patients with UGIB admitted to the tertiary Department of Gastroenterology between January 2013 and December 2020. A total of 1499 patients were enrolled in the study. One thousand four hundred and ninety-nine patients were hospitalized for 7 years with active upper digestive hemorrhage, 504 variceal bleeding, and 995 nonvariceal bleeding. When comparing variceal with nonvariceal bleeding, in nonvariceal bleeding, the mean age was higher, similar sex, higher mortality rate, higher rebleeding rate, and higher hemorrhagic shock rate. Endoscopy treatment was also performed more frequently in variceal bleeding than in nonvariceal bleeding. Severe anemia was found more frequently in patients with variceal bleeding. The mortality rate was 10% in the entire study group, which was not significantly different between the 2 batches. However, the rebleeding rate is higher in patients with variceal gastrointestinal bleeding.
急性上消化道出血(UGIB)是一种典型的医学急症,发病率为每 10 万人 84 至 160 例,死亡率约为 10%。本研究旨在确定在一家三级胃肠病学系住院的所有 UGIB 病例,确定再出血和死亡率的可能预测因素、不同因素之间的潜在关联与出血的严重程度以及非静脉曲张性和静脉曲张性出血之间的差异。这是一项对 2013 年 1 月至 2020 年 12 月在三级胃肠病学系住院的 UGIB 患者进行的观察性、回顾性研究。共有 1499 名患者纳入本研究。1499 名患者因活动性上消化道出血住院 7 年,其中静脉曲张性出血 504 例,非静脉曲张性出血 995 例。在比较静脉曲张性出血和非静脉曲张性出血时,在非静脉曲张性出血中,平均年龄较高,性别相似,死亡率、再出血率和出血性休克率较高。静脉曲张性出血比非静脉曲张性出血更常进行内镜治疗。静脉曲张性出血患者更常出现严重贫血。整个研究组的死亡率为 10%,两组之间无显著差异。然而,静脉曲张性胃肠道出血患者的再出血率较高。