BRCA2 基因突变与癌症。
BRCA2 gene mutation in cancer.
机构信息
Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Department of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
出版信息
Medicine (Baltimore). 2022 Nov 11;101(45):e31705. doi: 10.1097/MD.0000000000031705.
Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and prostate cancers. In this review, we discuss the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy.
乳腺癌易感基因 2（BRCA2）是与遗传性乳腺癌相关的主要基因。然而，BRCA2 中的突变也在其他肿瘤中被发现，如卵巢癌、胰腺癌、甲状腺癌、胃癌、喉癌和前列腺癌。在这篇综述中，我们讨论了 BRCA2 的生物学功能以及 BRCA2 突变在肿瘤进展和治疗中的作用。
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