Fu Chuhua, Wang Detian, Wang Long, Zhu Liguo, Li Zeren, Chen Tunan, Feng Hua, Li Fei
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China.
Department of Neurosurgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, People's Republic of China.
J Biophotonics. 2023 Apr;16(4):e202200168. doi: 10.1002/jbio.202200168. Epub 2022 Dec 4.
Rapid screening for ischemic strokes in prehospital settings may improve patient outcomes by allowing early deployment of vascular recanalization therapies. However, there are no low-cost and convenient methods that can assess ischemic strokes in such a setting. Diffuse correlation spectroscopy (DCS) is a promising method for continuous, noninvasive transcranial monitoring of cerebral blood flow. In this study, we used a DCS system to detect cerebral hemodynamics before and after acute ischemic stroke in pigs. Seven adult porcines were chosen to establish ischemic stroke models via bilateral common carotid artery ligation (n = 5) or air emboli (n = 2). The results showed a significant difference in blood flow index (BFI) between the normal and ischemic groups. Relative blood flow index (rBFI) exhibited excellent results. Therefore, the diffuse optical method can assess the hemodynamic changes in acute cerebral ischemic stroke onset in pigs, and rBFI may be a promising biomarker for identifying cerebral ischemic stroke.
在院前环境中对缺血性中风进行快速筛查，通过早期应用血管再通疗法，可能会改善患者的治疗效果。然而，目前尚无低成本且便捷的方法可在此类环境中评估缺血性中风。扩散相关光谱法（DCS）是一种用于连续、无创经颅监测脑血流的有前景的方法。在本研究中，我们使用DCS系统检测猪急性缺血性中风前后的脑血流动力学。选取7只成年猪，通过双侧颈总动脉结扎（n = 5）或空气栓塞（n = 2）建立缺血性中风模型。结果显示，正常组与缺血组之间的血流指数（BFI）存在显著差异。相对血流指数（rBFI）表现出优异的结果。因此，漫射光学方法可评估猪急性脑缺血性中风发作时的血流动力学变化，且rBFI可能是用于识别脑缺血性中风的一种有前景的生物标志物。
