漫射相关光谱法用于非侵入式、微血管脑血流测量。
Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement.
机构信息
ICFO- Institut de Ciències Fotòniques, Mediterranean Technology Park, 08860 Castelldefels, Barcelona, Spain.
出版信息
Neuroimage. 2014 Jan 15;85 Pt 1(0 1):51-63. doi: 10.1016/j.neuroimage.2013.06.017. Epub 2013 Jun 14.
Abstract
Diffuse correlation spectroscopy (DCS) uses the temporal fluctuations of near-infrared (NIR) light to measure cerebral blood flow (CBF) non-invasively. Here, we provide a brief history of DCS applications in the brain with an emphasis on the underlying physical ideas, common instrumentation and validation. Then we describe recent clinical research that employs DCS-measured CBF as a biomarker of patient well-being, and as an indicator of hemodynamic and metabolic responses to functional stimuli.
摘要
漫反射相关光谱（DCS）利用近红外（NIR）光的时间波动来无创地测量脑血流（CBF）。在这里，我们简要介绍了 DCS 在大脑中的应用历史，重点介绍了其基本物理原理、常见仪器和验证方法。然后，我们描述了最近的临床研究，这些研究将 DCS 测量的 CBF 用作患者健康状况的生物标志物，以及用于指示对功能刺激的血流动力学和代谢反应的指标。
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