Akhtar Muhammad Uzair, Pasha Talat Naseer, Avais Muhammad, Khan Nauman, Chishti Ghazanfar Ali, Ali Mubashar, Imran Muhammad, Tahir Muhammad Naeem, Naveed-Ul-Haque Muhammad
Department of Animal Nutrition, University of Veterinary & Animal Sciences, Outfall road, Lahore 54000, Pakistan.
Department of Livestock Production, University of Veterinary & Animal Sciences, Outfall road, Lahore 54000, Pakistan.
Anim Biosci. 2023 Jun;36(6):869-878. doi: 10.5713/ab.22.0218. Epub 2022 Nov 14.
Hyperketonemia remains a major metabolic issue of serious milk production and a major health concern in early lactation cows. Oral supplementation of glucose precursors (GP) can be used to prevent hyperketonemia in dairy cows. The objective of this study was to compare the beneficial effects of orally supplementing a mixture of GP on metabolic health indicators and milk production status of primiparous (PP) and multiparous (MP) dairy cows.
Twenty-eight Holstein cows were blocked by expected date of parturition, previous lactation yield, and parity. The cows were randomly allocated to one of the four treatment groups (n = 7 cows/group) based on their parity and GP supplementation: i) PP cows fed basal diet only (PP-CON), ii) PP cows with oral supplementation of GP (PP-GP), iii) MP cows fed basal diet only (MP-CON), and iv) MP cows with oral supplementation of GP (MP-GP). Glucose precursor (glycoline liquid) was orally drenched (300 mL/d) in GP cows from 7 days prepartum through 7 days postpartum. Other than GP supplementation, all cows were fed similar pre- and postpartum basal diets.
In both pre- and postpartum periods, serum glucose concentration was increased, whereas β-hydroxybutyrate and free fatty acids were decreased in GP cows compared with the CON cows. Milk yield and milk components were statistically not different between GP and CON cows over the first 9 week of lactation. The yield of actual milk, energy-corrected milk, 63-days cumulative milk, colostrum yield, and calf birth weight remained higher in MP cows compared with PP cows.
Oral drenching of GP around calving can be recommended to successfully improve the metabolic health and reduce the negative effects of hyperketonemia not only in MP but also in PP dairy cows.
高酮血症仍然是严重影响产奶量的主要代谢问题，也是初产奶牛早期健康的主要关注点。口服补充葡萄糖前体（GP）可用于预防奶牛高酮血症。本研究的目的是比较口服补充GP混合物对初产（PP）和经产（MP）奶牛代谢健康指标和产奶状况的有益影响。
28头荷斯坦奶牛按预计分娩日期、前一胎产奶量和胎次进行分组。根据奶牛的胎次和GP补充情况，将奶牛随机分为四个处理组之一（每组n = 7头奶牛）：i）仅饲喂基础日粮的初产奶牛（PP-CON），ii）口服补充GP的初产奶牛（PP-GP），iii）仅饲喂基础日粮的经产奶牛（MP-CON），iv）口服补充GP的经产奶牛（MP-GP）。从产前7天到产后7天，给GP组奶牛口服灌服葡萄糖前体（甘氨酸溶液，300 mL/天）。除补充GP外，所有奶牛在产前和产后均饲喂相似的基础日粮。
在产前和产后期间，与CON组奶牛相比，GP组奶牛的血清葡萄糖浓度升高，而β-羟基丁酸和游离脂肪酸降低。在泌乳的前9周，GP组和CON组奶牛的产奶量和乳成分在统计学上无差异。与初产奶牛相比，经产奶牛的实际产奶量、能量校正奶量、63天累计产奶量、初乳产量和犊牛出生体重仍然较高。
建议在产犊前后口服灌服GP，以成功改善代谢健康，不仅降低经产奶牛，也降低初产奶牛高酮血症的负面影响。
