Lange Marcia, Zaret Dina, Kushner Tatyana
Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Gastroenterol Hepatol (N Y). 2022 Sep;18(9):508-520.
Hepatitis delta virus (HDV) infection is caused by a unique circular RNA virus that relies on both the hepatitis B virus (HBV) antigen and human host polymerases for its transmission and replication. HDV infection can be acquired simultaneously with HBV as a coinfection or as a superinfection in patients already chronically infected with HBV. Chronic HDV is the most severe and progressive form of viral hepatitis-induced liver disease, accounting for significant morbidity and mortality worldwide. Despite the severity of disease and poor clinical outcomes, there are few therapeutic options for the treatment of HDV infection. This article discusses the epidemiology of HDV globally and in the United States, the diagnosis and clinical course of HDV infection, and the current and future therapeutic options for the management of HDV infection.
丁型肝炎病毒（HDV）感染是由一种独特的环状RNA病毒引起的，该病毒的传播和复制依赖于乙型肝炎病毒（HBV）抗原和人类宿主聚合酶。HDV感染可与HBV同时发生，表现为合并感染，也可发生在已慢性感染HBV的患者中，表现为重叠感染。慢性HDV是病毒性肝炎所致肝病中最严重、进展最快的形式，在全球范围内导致了显著的发病率和死亡率。尽管疾病严重且临床预后不佳，但治疗HDV感染的治疗选择却很少。本文讨论了HDV在全球和美国的流行病学、HDV感染的诊断和临床过程，以及HDV感染管理的当前和未来治疗选择。
