体力活动干预对活跃期转移性乳腺癌患者的影响：生活质量与功能。

Physical Activity Intervention in Patients with Metastatic Breast Cancer During Active Treatment: Quality of Life and Function.

机构信息

Division of Oncology, Sourasky - Tel Aviv Medical Center, Tel Aviv, Israel.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Oncologist. 2023 Jan 18;28(1):84-e70. doi: 10.1093/oncolo/oyac232.

DOI:10.1093/oncolo/oyac232

PMID:36398879

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9847548/

Abstract

BACKGROUND

In this study, we explore recruitment, retention, and potential quality of life (QoL) and function benefits from a self-directed, home-based walking intervention in women during active treatment for metastatic breast cancer (MBC).

METHODS

In this single-arm pilot study, women with stage IV BC wore an activity tracker (FitbitTM) to measure steps per week throughout the intervention study. Participants were asked to walk 150 min per week at a comfortable and safe pace. Patient-reported outcome measures (PRO) were collected at baseline and follow-up.

RESULTS

Target recruitment of 60 patients was achieved. In 52 patients who completed all baseline measures, mean age was 55 (SD 11.1), 23% were pre-menopausal, and 19% non-White. Forty patients (77%) were retained at 3 months and 29 (56%) at 6 months. Baseline walking was the strongest predictor of retention at 3 months (P = .02). For 24 patients (46%) with analyzable Fitbit data at 3 months, mean steps/week rose from 19,175 to 31,306. Higher number of steps correlated with larger improvements FACT-G General well-being (FACT-G, rho = 0.55, P = .01), FACT-G Physical well-being (rho = 0.48, P = .03), and PROMIS Mental Health (rho = 0.55, P = .01).

CONCLUSION

Recruitment into a walking intervention is feasible (a priory target of N = 60) in women during treatment for MBC, but retention at 3 months follow-up fell short (77% versus a priori 80%), yet there were potential benefits in general and physical well-being and mental health.

CLINICALTRIALS.GOV IDENTIFIER: NCT02682836.

摘要

背景

本研究旨在探讨一项针对转移性乳腺癌（MBC）活跃期女性的自我指导、家庭为基础的步行干预措施的招募、保留情况以及潜在的生活质量（QoL）和功能获益。

方法

在这项单臂试点研究中，患有 IV 期 BC 的女性佩戴活动追踪器（FitbitTM），以在整个干预研究期间每周测量步数。参与者被要求以舒适且安全的速度每周行走 150 分钟。在基线和随访时收集患者报告的结果测量指标（PRO）。

结果

成功招募了 60 名患者。在完成所有基线测量的 52 名患者中，平均年龄为 55 岁（标准差 11.1），23%处于绝经前，19%是非白人。40 名患者（77%）在 3 个月时保留，29 名患者（56%）在 6 个月时保留。基线行走是 3 个月时保留的最强预测因素（P=0.02）。对于 24 名在 3 个月时有可分析 Fitbit 数据的患者（46%），每周平均步数从 19175 上升至 31306。较高的步数与更大的 FACT-G 总体健康状况（FACT-G，rho=0.55，P=0.01）、FACT-G 身体状况（rho=0.48，P=0.03）和 PROMIS 心理健康（rho=0.55，P=0.01）改善呈正相关。