Lee Che Young, Laffoon Kylee, Mama Scherezade K, Liao Yue, Whisenant Meagan, Brewster Abenaa, Mendoza Tito, Mitchell Stacy J, Tracy Patricia V, Garza Giselle M, Basen-Engquist Karen M
Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 1440, Houston, TX, 77030, USA.
Department of Kinesiology, The University of Texas at Arlington, 500 W. Nedderman Dr. 147, Arlington, TX, 76019, USA.
J Cancer Surviv. 2024 May 27. doi: 10.1007/s11764-024-01600-8.
This study examined the effectiveness and feasibility of the Active Living After Cancer (ALAC) program for metastatic breast cancer (MBC) survivors.
ALAC is a 12-session community-based program to help cancer survivors improve their physical functioning and quality of life through increased physical activity. ALAC participants with MBC (stage IV) were compared to survivors with early-stage breast cancer (stages I and II). The International Physical Activity Questionnaire, Godin Leisure-Time Physical Activity, 30-second sit-to-stand test, and PROMIS Global Health were administered at baseline and follow-up. Program satisfaction and retention were assessed at week 12. Repeated-measures mixed models were used to compare changes in outcomes between survivors with early-stage breast cancer and MBC.
A total of 585 women (59.3 y ± 10.6), most of whom were Hispanic (54%) or non-Hispanic Black (22%), were included (early stage, n = 538; MBC, n = 47). After the ALAC program, a significant increase in physical activity (P < 0.001), improved physical and mental health T-scores (P < 0.001), and more sit-to-stand repetitions (P < 0.001) were observed for both survivors with early-stage breast cancer and MBC. Women with MBC showed significantly lower physical health (P = 0.037) and physical function (P = 0.010) compared to early-stage at baseline.
The ALAC program increased physical activity and improved health-related quality of life and physical function among breast cancer survivors with both early-stage and metastatic disease.
This study emphasizes the importance of incorporating physical activity interventions like the ALAC program into the comprehensive care of cancer survivors, including those with metastatic disease.
本研究探讨了癌症后积极生活（ALAC）项目对转移性乳腺癌（MBC）幸存者的有效性和可行性。
ALAC是一个基于社区的项目，共12节课程，旨在通过增加身体活动帮助癌症幸存者改善身体机能和生活质量。将患有MBC（IV期）的ALAC参与者与早期乳腺癌（I期和II期）幸存者进行比较。在基线和随访时进行国际身体活动问卷、戈丁休闲时间身体活动、30秒坐立测试和PROMIS全球健康评估。在第12周评估项目满意度和留存率。采用重复测量混合模型比较早期乳腺癌幸存者和MBC幸存者之间的结局变化。
共纳入585名女性（59.3岁±10.6岁），其中大多数为西班牙裔（54%）或非西班牙裔黑人（22%）（早期，n = 538；MBC，n = 47）。在ALAC项目后，早期乳腺癌幸存者和MBC幸存者的身体活动均显著增加（P < 0.001），身心健康T评分改善（P < 0.001），坐立重复次数增多（P < 0.001）。与基线时的早期患者相比，MBC女性的身体健康（P = 0.037）和身体机能（P = 0.010）显著更低。
ALAC项目增加了早期和转移性乳腺癌幸存者的身体活动，改善了与健康相关的生活质量和身体机能。
本研究强调了将像ALAC项目这样的身体活动干预纳入癌症幸存者综合护理的重要性，包括那些患有转移性疾病的幸存者。
