Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden.
Helsingborg's Hospital, Helsingborg, Sweden.
Contact Dermatitis. 2023 Mar;88(3):206-211. doi: 10.1111/cod.14249. Epub 2022 Nov 25.
Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions.
To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population.
A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch-test database.
Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone-positive patients had higher mean age, were significantly more likely female (p < 0.001) and had often an intraoral/lip involvement (p < 0.001). In the carvone-positive group, 50% (n = 14) had a relevant reaction, and in 4 of 14, the relevance was first revealed after test reading. Of the carvone-positive patients, 18 of 28 did not have a coexisting allergy to a fragrance/flavour allergen and of these 44% had a relevant allergy.
The study suggests that a significant fraction of relevant carvone contact allergies may be overlooked if the allergen is not tested. Furthermore, as the exposure is widespread, inclusion of carvone in the Swedish baseline series may be justified even if the contact allergy prevalence is below 1%.
香芹酮（l-香芹酮）是一种薄荷味的风味添加剂，我们大多数人都会接触到它，并可能引起过敏接触反应。
分析接触性皮炎患者中香芹酮阳性反应的频率和相关性。
对 2017 年至 2021 年连续接受香芹酮测试的接触性皮炎患者进行回顾性分析。数据从部门的斑贴试验数据库中检索。
在 3554 名接受香芹酮测试的患者中，有 28 名（0.79%）出现阳性反应。香芹酮阳性患者的平均年龄较高，女性明显更多（p<0.001），且常伴有口腔/唇部受累（p<0.001）。在香芹酮阳性组中，50%（n=14）有相关反应，其中 4 例在测试阅读后首次显示相关反应。在香芹酮阳性患者中，28 名中的 18 名没有同时对香料/风味过敏原过敏，其中 44%有相关过敏。
该研究表明，如果不测试过敏原，可能会忽略相当一部分与香芹酮相关的接触过敏。此外，由于接触广泛，即使接触过敏的患病率低于 1%，瑞典基础系列中也可能包含香芹酮。
