Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Hematol Oncol Clin North Am. 2022 Dec;36(6):1151-1165. doi: 10.1016/j.hoc.2022.06.009.
Chronic pain is a distinct complication that profoundly affects the lives of individuals with sickle cell disease (SCD). Chronic SCD pain emerges with increasing age and is very prevalent in adults. The pathophysiology of chronic SCD pain is likely distinct from acute SCD pain and therefore needs a different treatment approach. Clinical trials evaluating the treatment of chronic SCD pain are lacking and treatment currently relies on evidence from other chronic pain conditions. Continued investigations into the underlying causes of chronic SCD pain are needed, and clinical trials focused on chronic pain therapy are imperative.
慢性疼痛是一种明显的并发症，深刻地影响着镰状细胞病（SCD）患者的生活。慢性 SCD 疼痛随着年龄的增长而出现，在成年人中非常普遍。慢性 SCD 疼痛的病理生理学可能与急性 SCD 疼痛不同，因此需要不同的治疗方法。目前缺乏评估慢性 SCD 疼痛治疗的临床试验，治疗方法主要依赖于其他慢性疼痛疾病的证据。需要进一步研究慢性 SCD 疼痛的根本原因，并开展专注于慢性疼痛治疗的临床试验。
