Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China.
Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
Diabetes Metab Res Rev. 2023 Feb;39(2):e3596. doi: 10.1002/dmrr.3596. Epub 2022 Nov 30.
The pathogenic mechanism of diabetic kidney disease (DKD) is involved in various functions; however, its inadequate characterisation limits the availability of effective treatments. Tubular damage is closely correlated with renal function and is thought to be the main contributor to the injury observed in early DKD. Programed cell death (PCD) occurs during the biological development of the living body. Accumulating evidence has clarified the fundamental role of abnormalities in tubular PCD during DKD pathogenesis. Among PCD types, classical apoptosis, autophagic cell death, and pyroptosis are the most studied and will be the focus of this review. Our review aims to elucidate the current knowledge of the mechanism of DKD and the potential therapeutic potential of drugs targeting tubular PCD pathways in DKD.
糖尿病肾病（DKD）的发病机制涉及多种功能；然而，其特征描述不足限制了有效治疗方法的应用。肾小管损伤与肾功能密切相关，被认为是早期 DKD 观察到的损伤的主要原因。程序性细胞死亡（PCD）发生在生物体的生物发育过程中。越来越多的证据阐明了 DKD 发病机制中肾小管 PCD 异常的基本作用。在 PCD 类型中，经典凋亡、自噬细胞死亡和细胞焦亡是研究最多的，将是本综述的重点。我们的综述旨在阐明 DKD 的发病机制以及针对 DKD 中肾小管 PCD 途径的药物的潜在治疗潜力的现有知识。
